AJP - Regulatory, Integrative and Comparative Physiology, Vol 256, Issue 3 694-R700, Copyright © 1989 by American Physiological Society

ARTICLES

Central effect of angiotensin II on baroreflex regulation in conscious rabbits

Y. Matsumura, E. M. Hasser and V. S. Bishop
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764.

Central effects of angiotensin II (ANG II) on arterial baroreflex control of renal sympathetic nerve activity (RSNA) and heart rate (HR) were examined in conscious rabbits. Intravenous infusions of ANG II (5-320 ng.kg-1.min-1) significantly reduced the baroreflex inhibition of HR compared with phenylephrine (PE) (0.5-16 micrograms.kg-1.min-1), whereas reflex inhibition of RSNA was unaltered. Background intravenous infusions of ANG II did not alter the baroreflex responses of RSNA nor HR to increases (with PE) or decreases in mean arterial pressure (with nitroglycerin or inferior vena cava occluder). When ANG II was infused into the vertebral artery (VA) the integrated pressor response was greater than intravenous infusions. Progressive VA infusions of ANG II resulted in a significantly blunted baroreflex inhibition of HR compared with intravenous infusions, whereas the reflex inhibition of RSNA was identical between VA and intravenous infusions. These results suggest that ANG II produces central pressor effects via a hindbrain site and reduces baroreflex inhibition of HR without altering baroreflex inhibition of RSNA.

This article has been cited by other articles:

				P. S. P. Tan, S. Killinger, J. Horiuchi, and R. A. L. Dampney Baroreceptor reflex modulation by circulating angiotensin II is mediated by AT1 receptors in the nucleus tractus solitarius Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2267 - R2278. [Abstract] [Full Text] [PDF]

				C. Call, S. Han, J. E. Speich, T. J. Eddinger, and P. H. Ratz Resistance to pressure-induced dilatation in femoral but not saphenous artery: physiological role of latch? Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1513 - H1520. [Abstract] [Full Text] [PDF]

				A. C. Alzamora, R. A. S. Santos, and M. J. Campagnole-Santos Baroreflex modulation by angiotensins at the rat rostral and caudal ventrolateral medulla Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R1027 - R1034. [Abstract] [Full Text] [PDF]

				Y.-F. Li, W. Wang, W. G. Mayhan, and K. P. Patel Angiotensin-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R1035 - R1043. [Abstract] [Full Text] [PDF]

				B. Xue, J. Pamidimukkala, and M. Hay Sex differences in the development of angiotensin II-induced hypertension in conscious mice Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2177 - H2184. [Abstract] [Full Text] [PDF]

				J. Pamidimukkala, B. Xue, L. G. Newton, D. B. Lubahn, and M. Hay Estrogen receptor-{alpha} mediates estrogen facilitation of baroreflex heart rate responses in conscious mice Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1063 - H1070. [Abstract] [Full Text] [PDF]

				J. Pamidimukkala and M. Hay 17{beta}-Estradiol inhibits angiotensin II activation of area postrema neurons Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1515 - H1520. [Abstract] [Full Text] [PDF]

				J. Pamidimukkala, J. A. Taylor, W. V. Welshons, D. B. Lubahn, and M. Hay Estrogen modulation of baroreflex function in conscious mice Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R983 - R989. [Abstract] [Full Text] [PDF]

				B. Xue, H. Gole, J. Pamidimukkala, and M. Hay Role of the area postrema in angiotensin II modulation of baroreflex control of heart rate in conscious mice Am J Physiol Heart Circ Physiol, March 1, 2003; 284(3): H1003 - H1007. [Abstract] [Full Text] [PDF]

				L. Xu and A. F. Sved Acute sympathoexcitatory action of angiotensin II in conscious baroreceptor-denervated rats Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R451 - R459. [Abstract] [Full Text] [PDF]

				M. G. Sanderford and V. S. Bishop Central mechanisms of acute ANG II modulation of arterial baroreflex control of renal sympathetic nerve activity Am J Physiol Heart Circ Physiol, May 1, 2002; 282(5): H1592 - H1602. [Abstract] [Full Text] [PDF]

				M. P. Massett, S. J. Lewis, H. M. Stauss, and K. C. Kregel Vascular reactivity and baroreflex function during hyperthermia in conscious rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1282 - R1289. [Abstract] [Full Text] [PDF]

				M. G. Sanderford and V. S. Bishop Angiotensin II acutely attenuates range of arterial baroreflex control of renal sympathetic nerve activity Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1804 - H1812. [Abstract] [Full Text] [PDF]

				M. Johansson, M. Elam, B. Rundqvist, G. Eisenhofer, H. Herlitz, G. Jensen, and P. Friberg Differentiated Response of the Sympathetic Nervous System to Angiotensin-Converting Enzyme Inhibition in Hypertension Hypertension, October 1, 2000; 36(4): 543 - 548. [Abstract] [Full Text] [PDF]

				Q. Li, M. J. Sullivan, W. E. Dale, E. M. Hasser, E. H. Blaine, and J. T. Cunningham Fos-Like Immunoreactivity in the Medulla after Acute and Chronic Angiotensin II Infusion J. Pharmacol. Exp. Ther., March 1, 1998; 284(3): 1165 - 1173. [Abstract] [Full Text]

				J. S. Kooner, C. N. May, S. Peart, and C. J. Mathias Separation of peripheral and central cardiovascular actions of angiotensin II Am J Physiol Heart Circ Physiol, December 1, 1997; 273(6): H2620 - H2626. [Abstract] [Full Text] [PDF]

				D. B. Averill, K. Matsumura, D. Ganten, and C. M. Ferrario Role of Area Postrema in Transgene Hypertension Hypertension, March 1, 1996; 27(3): 591 - 597. [Abstract] [Full Text]

				B. S. Huang and F. H. H. Leenen Brain `Ouabain' and Desensitization of Arterial Baroreflex by High Sodium in Dahl Salt-Sensitive Rats Hypertension, March 1, 1995; 25(3): 372 - 376. [Abstract] [Full Text]