| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 256, Issue 3 739-R750, Copyright © 1989 by American Physiological Society
ARTICLES |
J. R. Haselton and P. G. Guyenet
Department of Pharmacology, University of Virginia, Charlottesville 22908.
The central respiratory generator exerts a modulatory influence on sympathetic nerve discharge. In cats the sympathoexcitatory neurons of the rostroventrolateral medulla (RVL) exhibit central respiratory modulation as well. Because RVL sympathoexcitatory neurons are largely responsible for the maintenance of sympathetic vasomotor tone, it is likely that the modulation of these neurons accounts for the central respiratory modulation of sympathetic discharge. In the present study experiments were performed to characterize the pattern of respiratory modulation of lumbar sympathetic nerve discharge (LSND) in the halothane-anesthetized rat. Phrenic-triggered averaging of LSND exhibited a small depression coincident with the onset of the phrenic burst followed by a large peak that was coincident with the cessation of the phrenic burst. Phrenic-triggered histograms of the activity of RVL sympathoexcitatory neurons exhibited three patterns of central respiratory modulation: inspiratory depression (I), inspiratory peak (II), and early inspiratory depression followed by a postinspiratory peak (III), a pattern that was very similar to that seen in LSND. Both nerve recording and single-unit recording experiments were performed in vagotomized rats with or without intact barosensory afferents. A comparison of the results suggested that, in the rat, the baroreflex does not modify or contribute to the central respiratory modulation of sympathetic output. Finally, a comparison was made between presumed nonadrenergic pacemaker-like neurons and putative C1 adrenergic neurons in the RVL. No differences were found in the patterns of central respiratory modulation.
This article has been cited by other articles:
|
|
 |
|
  D. A. Mandel and A. M. Schreihofer Glutamatergic inputs to the CVLM independent of the NTS promote tonic inhibition of sympathetic vasomotor tone in rats Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1772 - H1779. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Green and D. J. Paterson Identification of neurocircuitry controlling cardiovascular function in humans using functional neurosurgery: implications for exercise control Exp Physiol, September 1, 2008; 93(9): 1022 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Zoccal, A. E. Simms, L. G. H. Bonagamba, V. A. Braga, A. E. Pickering, J. F. R. Paton, and B. H. Machado Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity J. Physiol., July 1, 2008; 586(13): 3253 - 3265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Coote Landmarks in understanding the central nervous control of the cardiovascular system Exp Physiol, January 1, 2007; 92(1): 3 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Moreira, A. C. Takakura, E. Colombari, and P. G. Guyenet Central chemoreceptors and sympathetic vasomotor outflow J. Physiol., November 15, 2006; 577(1): 369 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Mobley, D. A. Mandel, and A. M. Schreihofer Systemic Cholecystokinin Differentially Affects Baro-activated GABAergic Neurons in Rat Caudal Ventrolateral Medulla J Neurophysiol, November 1, 2006; 96(5): 2760 - 2768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Mandel and A. M. Schreihofer Central respiratory modulation of barosensitive neurones in rat caudal ventrolateral medulla J. Physiol., May 1, 2006; 572(3): 881 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Schreihofer, S. Ito, and A. F. Sved Brain stem control of arterial pressure in chronic arterial baroreceptor-denervated rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1746 - R1755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Phillips, G. L. Gebber, and S. M. Barman Medullary lateral tegmental field: control of respiratory rate and vagal lung inflation afferent influences on sympathetic nerve discharge Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1396 - R1410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Dick, Y.-H. Hsieh, S. Morrison, S. K. Coles, and N. Prabhakar Entrainment pattern between sympathetic and phrenic nerve activities in the Sprague-Dawley rat: hypoxia-evoked sympathetic activity during expiration Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1121 - R1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-H. Cao and S. F. Morrison Differential chemoreceptor reflex responses of adrenal preganglionic neurons Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R1825 - R1832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Morrison Differential control of sympathetic outflow Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R683 - R698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. McAllen, D. Trevaks, and A. M. Allen Analysis of Firing Correlations Between Sympathetic Premotor Neuron Pairs in Anesthetized Cats J Neurophysiol, April 1, 2001; 85(4): 1697 - 1708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-J. Habler, T. Bartsch, and W. Janig Rhythmicity in Single Fiber Postganglionic Activity Supplying the Rat Tail J Neurophysiol, May 1, 1999; 81(5): 2026 - 2036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Hilaire and B. Duron Maturation of the Mammalian Respiratory System Physiol Rev, April 1, 1999; 79(2): 325 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. E. Greenberg, A. Sica, D. Batson, and S. M. Scharf Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia J Appl Physiol, January 1, 1999; 86(1): 298 - 305. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
