AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 256: R772-R777, 1989;
0363-6119/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cornell, R. P.
Right arrow Articles by Schwartz, D. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cornell, R. P.
Right arrow Articles by Schwartz, D. B.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 256, Issue 3 772-R777, Copyright © 1989 by American Physiological Society

ARTICLES

Central administration of interleukin 1 elicits hyperinsulinemia in rats

R. P. Cornell and D. B. Schwartz
Division of Science, Northeast Missouri State University, Kirksville 63501.

This laboratory previously demonstrated that human natural interleukin 1 (IL-1) administered intravenously at a dose of 50 U to conscious fasted male Holtzman rats elicited unstimulated as well as glucose- and arginine-stimulated hyperinsulinemia. The major question posed in the present investigation is whether the monokine IL-1 can act centrally on an area of the brain such as the preoptic area of the anterior hypothalamus, which participates in mediating the IL-1-induced febrile response, to elicit insulin secretion by the pancreas. Therefore, for this study, injections of IL-1 were administered intravenously (iv), intracerebroventricularly (icv), or into the preoptic area of the anterior hypothalamus (iPO) in pentobarbital-anesthetized fasted rats. Preliminary experiments determined that the hyperinsulinemic response was enhanced in anesthetized compared with conscious animals treated iv with IL-1. An icv administered 10-U dose of the monokine produced a delayed hyperinsulinemia equal to two times the saline control value starting near 20 min postinjection but declining quickly. When injected iPO, 5 U of IL-1 elicited a prompt substantial hyperinsulinemia equal to more than three times control beginning at 5 min postinjection and persisting through the 30-min experimental period. These findings indicate that an IL-1-induced signal for pancreatic insulin secretion can be generated within the central nervous system.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Monroy, J. W. Kuluz, D. He, W. D. Dietrich, and C. L. Schleien
Role of nitric oxide in the cerebrovascular and thermoregulatory response to interleukin-1{beta}
Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1448 - H1453.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online