AJP - Regu AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 256: R792-R796, 1989;
0363-6119/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morita, H.
Right arrow Articles by Hosomi, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morita, H.
Right arrow Articles by Hosomi, H.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 256, Issue 3 792-R796, Copyright © 1989 by American Physiological Society

ARTICLES

Effects of brain natriuretic peptide on renal nerve activity in conscious rabbits

H. Morita, Y. Nishida, H. Motochigawa, K. Kangawa, N. Minamino, H. Matsuo and H. Hosomi
Department of Physiology, Kagawa Medical School, Japan.

Responses of renal nerve activity (RNA) to intravenous infusion of brain natriuretic peptide (BNP) were examined in chronically instrumented conscious rabbits with all baroreflexes intact, sinoaortic baroreceptor denervation (SAD), and SAD plus vagotomy. In intact rabbits, an infusion of BNP at a rate of 0.3 microgram.kg-1.min-1 for 30 min decreased mean arterial pressure (MAP) by 8 +/- 1 mmHg and increased RNA by 48 +/- 4% but did not alter heart rate (HR). The decrease in MAP in SAD rabbits (20 +/- 3 mmHg) was greater than in intact rabbits, whereas RNA increased less (21 +/- 7%). After SAD plus vagotomy, BNP lowered MAP by 25 +/- 4 mmHg, whereas RNA was not altered significantly. To further examine the effects of BNP on baroreflex control of HR and RNA, the baroreceptors were stimulated or unloaded by raising or lowering MAP by injections of phenylephrine or glyceryl trinitrate, respectively. The maximum change in each HR or RNA response to phenylephrine or glyceryl trinitrate was plotted against the maximum change in each MAP response and a logistic function curve was fitted to the MAP-HR and MAP-RNA relationship. BNP did not alter the slope of either curve but shifted both curves to the left. These results indicate that 1) in intact rabbits, BNP increases RNA due to sinoaortic and cardiopulmonary baroreflexes and 2) BNP resets the baroreflex control of HR and RNA to a lower arterial pressure.


This article has been cited by other articles:


Home page
 CirculationHome page
L. S. Marcus, D. Hart, M. Packer, M. Yushak, N. Medina, R. S. Danziger, D. F. Heitjan, and S. D. Katz
Hemodynamic and Renal Excretory Effects of Human Brain Natriuretic Peptide Infusion in Patients With Congestive Heart Failure: A Double-Blind, Placebo-Controlled, Randomized Crossover Trial
Circulation, December 15, 1996; 94(12): 3184 - 3189.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online