AJP - Regulatory, Integrative and Comparative Physiology, Vol 256, Issue 5 1138-R1141, Copyright © 1989 by American Physiological Society

ARTICLES

Cholecystokinin-induced anorexia depends on serotoninergic function

D. Stallone, S. Nicolaidis and J. Gibbs
Centre National de la Recherche Scientifique, College de France, Paris.

The existence of a relationship between cholecystokinin (CCK)-induced satiety and the serotoninergic system was evaluated. The food intake of 3-h-fasted male rats was studied after treatment with the COOH-terminal octapeptide of CCK (CCK-8) alone or in combination with one of two blockers of serotonin (5-HT) receptors, metergoline (MET; 1.0 or 0.06 mg/kg), active in both the periphery and brain, or xylamidine tosylate (XYL; 1.5 mg/kg), active only in the periphery. CCK-8 reduced food intake in the 30 min after food presentation by 37% at 2 micrograms/kg, 68% at 4 micrograms/kg, and 80% at 8 micrograms/kg compared with controls. Both doses of MET attenuated CCK-8-induced satiety, increasing food intake of rats treated with all doses of CCK-8 to control values. Food intake was significantly increased over base line by the 1.0-mg/kg dose of MET alone but unaffected by the 0.06-mg/kg dose of MET alone. XYL had no effect either given alone or in combination with CCK-8. These results indicate that the inhibitory action of CCK-8 on food intake is dependent on intact functioning of the serotoninergic system, probably at central sites.

This article has been cited by other articles:

				T. A. Lutz Hunger and satiety: one brain for two? Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R900 - R902. [Full Text] [PDF]

				S. Aja Serotonin-3 receptors in gastric mechanisms of cholecystokinin-induced satiety Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R112 - R114. [Full Text] [PDF]

				D. M. Savastano, M. Carelle, and M. Covasa Serotonin-type 3 receptors mediate intestinal Polycose- and glucose-induced suppression of intake Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1499 - R1508. [Abstract] [Full Text] [PDF]

				C. M. Cannon and R. D. Palmiter Peptides that Regulate Food Intake: Norepinephrine is not required for reduction of feeding induced by cholecystokinin Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1384 - R1388. [Abstract] [Full Text] [PDF]

				A. Mollet, T. A. Lutz, S. Meier, T. Riediger, P. A. Rushing, and E. Scharrer Histamine H1 receptors mediate the anorectic action of the pancreatic hormone amylin Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1442 - R1448. [Abstract] [Full Text] [PDF]

				D. M. Bailey, B. Davies, L. M. Castell, E. A. Newsholme, and J. Calam Physical exercise and normobaric hypoxia: independent modulators of peripheral cholecystokinin metabolism in man J Appl Physiol, January 1, 2001; 90(1): 105 - 113. [Abstract] [Full Text] [PDF]