AJP - Regulatory, Integrative and Comparative Physiology, Vol 257, Issue 1 15-R20, Copyright © 1989 by American Physiological Society
Interaction of CCK-8 and somatostatin-14 in control of food intake in dogs
T. J. Kalogeris, R. D. Reidelberger, V. E. Mendel and T. E. Solomon
Department of Animal Physiology, University of California, Davis 95616.
interactions of cholecystokinin COOH-terminal octapeptide (CCK-8) and
somatostatin-14 (SS-14) on food intake in dogs were examined by
administration of graded doses of these peptides alone and in combination.
In animals fasted 19 h, SS-14 (2,000 or 20,000 pmol.kg-1.h-1) had no effect
on food intake. In animals fasted 4 h, food intake was not affected by 40
or 400 pmol.kg-1.h-1 SS-14 but was significantly (P less than 0.05)
increased by 20% after 4,000 pmol.kg-1.h-1 SS-14. Feeding responses to
simultaneous infusions of CCK-8 (50 or 400 pmol.kg-1.h-1) and SS-14 (40,
400, or 4,000 pmol.kg-1.h-1) were determined in animals fasted 4 h. Given
alone, the high dose of CCK-8 (400 pmol.kg-1.h-1) significantly (P less
than 0.01) depressed food intake by 55%. This effect was blocked by all
doses of SS-14. In the absence of CCK-8, SS-14 had no effect except at the
highest dose (4,000 pmol.kg-1.h-1), which significantly (P less than 0.01)
stimulated food intake by 57%. This effect was blocked by both doses of
CCK-8. Simultaneous infusion of lower doses of SS-14 (40 and 400
pmol.kg-1.h-1) and CCK-8 (50 pmol.kg-1.h-1) had no effect on food intake.
These results suggest that plasma levels of CCK and SS-14 after a meal are
not sufficient alone or in combination to produce satiety.
