AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 257: R174-R179, 1989;
0363-6119/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Valentin, J. P.
Right arrow Articles by Mimran, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Valentin, J. P.
Right arrow Articles by Mimran, A.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 257, Issue 1 174-R179, Copyright © 1989 by American Physiological Society

ARTICLES

Effect of nicardipine and atriopeptin on transcapillary shift of fluid and proteins

J. P. Valentin, J. Ribstein and A. Mimran
Department of Medicine, Centre Hospitalier Universitaire, Montpellier, France.

The possibility that calcium antagonists may alter extracellular fluid partition, as already suggested for atrial natriuretic peptide (ANP), was explored in anephric anesthetized rats by measuring changes in hematocrit and plasma proteins during infusion of synthetic ANP-(103-126) and the dihydropyridine derivative nicardipine. In response to ANP (1 micrograms.kg-1.min-1) or nicardipine (0.1 microgram.kg-1.min-1), which had a similar effect on arterial pressure, hematocrit increased by 9 +/- 0.1 and 5.4 +/- 0.3%, respectively, whereas plasma protein concentration increased to a lesser extent (3.9 +/- 0.3 and 3.7 +/- 0.2%, respectively). The simultaneous infusion of ANP and nicardipine had no additive effect on hematocrit, whereas the effect on arterial pressure was markedly enhanced. In additional experiments, an attempt was made to estimate the vascular leak of albumin in various tissues, using a quantitative Evans blue technique. Both ANP and nicardipine increased dye extravasation in skeletal and cardiac muscle, whereas ANP but not nicardipine increased extravasation in intestine. No significant change was observed in brain, liver, and lungs. These results suggest that nicardipine and ANP reduce plasma volume by an extrarenal mechanism. This fluid shift, possibly resulting from hemodynamic changes at the capillary level, is associated with a marked transfer of plasma albumin out of the vascular compartment.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Hempel, T. Noll, C. Bach, H. M. Piper, R. Willenbrock, K. Hohnel, H. Haller, and F. C. Luft
Atrial natriuretic peptide clearance receptor participates in modulating endothelial permeability
Am J Physiol Heart Circ Physiol, November 1, 1998; 275(5): H1818 - H1825.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Taherzadeh, A. K. Das, and J. B. Warren
Nifedipine increases microvascular permeability via a direct local effect on postcapillary venules
Am J Physiol Heart Circ Physiol, October 1, 1998; 275(4): H1388 - H1394.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J.-P. Valentin, W.-Z. Ying, W. G. Couser, and M. H. Humphreys
Extrarenal resistance to atrial natriuretic peptide in rats with experimental nephrotic syndrome
Am J Physiol Renal Physiol, March 1, 1998; 274(3): F556 - F563.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. S. E. Albert, V. L. Tucker, and E. M. Renkin
Acute alveolar hypoxia increases blood-to-tissue albumin transport: role of atrial natriuretic peptide
J Appl Physiol, January 1, 1997; 82(1): 111 - 117.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online