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AJP - Regulatory, Integrative and Comparative Physiology, Vol 257, Issue 5 1141-R1146, Copyright © 1989 by American Physiological Society
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T. A. Davis, M. L. Fiorotto, H. V. Nguyen and P. J. Reeds
United States Department of Agriculture, Baylor College of Medicine, Houston, Texas 77030.
To determine the normal changes in protein turnover of skeletal muscle in vivo during the suckling period of rats, protein synthesis was measured in soleus, plantaris, anterior tibialis, and extensor digitorum longus (EDL) muscles of 1- to 28-day-old rats using a flooding dose of L-[4-3H]phenylalanine. Protein mass of hind-limb muscles increased nearly 100-fold, and RNA increased approximately 20-fold between 1 and 28 days of age. The total amount of protein synthesized per day increased 34-fold. Fractional protein synthesis rates (Ks) decreased two- to threefold between 1 and 28 days postpartum as a result of a decrease in protein synthetic capacity (RNA/protein). Protein synthetic efficiency (total protein synthesized/RNA) increased during this period. Ks were similar among the four muscles at 1-10 days. At 16 days, Ks increased in soleus and plantaris as a result of increases in protein synthetic efficiency; Ks did not increase in anterior tibialis and EDL. These data suggest that, during the suckling period, protein synthetic capacity in skeletal muscles of rats declines, while protein synthetic efficiency increases. The increase in translational efficiency occurred earlier in weight-bearing muscles (soleus, plantaris) than in non-weight-bearing muscles (anterior tibialis and EDL) and was associated with the appearance of mobility.
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T. A. Davis, M. L. Fiorotto, P. R. Beckett, D. G. Burrin, P. J. Reeds, D. Wray-Cahen, and H. V. Nguyen Differential effects of insulin on peripheral and visceral tissue protein synthesis in neonatal pigs Am J Physiol Endocrinol Metab, May 1, 2001; 280(5): E770 - E779. [Abstract] [Full Text] [PDF]
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T. A. Davis, H. V. Nguyen, A. Suryawan, J. A. Bush, L. S. Jefferson, and S. R. Kimball Developmental changes in the feeding-induced stimulation of translation initiation in muscle of neonatal pigs Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1226 - E1234. [Abstract] [Full Text] [PDF]
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T. A. Davis, M. L. Fiorotto, H. V. Nguyen, and D. G. Burrin Aminoacyl-tRNA and tissue free amino acid pools are equilibrated after a flooding dose of phenylalanine Am J Physiol Endocrinol Metab, July 1, 1999; 277(1): E103 - E109. [Abstract] [Full Text] [PDF]
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D. Wray-Cahen, H. V. Nguyen, D. G. Burrin, P. R. Beckett, M. L. Fiorotto, P. J. Reeds, T. J. Wester, and T. A. Davis Response of skeletal muscle protein synthesis to insulin in suckling pigs decreases with development Am J Physiol Endocrinol Metab, October 1, 1998; 275(4): E602 - E609. [Abstract] [Full Text] [PDF]
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T. A. Davis, D. G. Burrin, M. L. Fiorotto, P. J. Reeds, and F. Jahoor Roles of Insulin and Amino Acids in the Regulation of Protein Synthesis in the Neonate J. Nutr., February 1, 1998; 128(2): 347 - 347. [Abstract] [Full Text]
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S. R. Kimball, P. A. Farrell, H. V. Nguyen, L. S. Jefferson, and T. A. Davis Developmental decline in components of signal transduction pathways regulating protein synthesis in pig muscle Am J Physiol Endocrinol Metab, March 1, 2002; 282(3): E585 - E592. [Abstract] [Full Text] [PDF]
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T. A. Davis, M. L. Fiorotto, D. G. Burrin, P. J. Reeds, H. V. Nguyen, P. R. Beckett, R. C. Vann, and P. M. J. O'Connor Stimulation of protein synthesis by both insulin and amino acids is unique to skeletal muscle in neonatal pigs Am J Physiol Endocrinol Metab, April 1, 2002; 282(4): E880 - E890. [Abstract] [Full Text] [PDF]
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