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Am J Physiol Regul Integr Comp Physiol 257: R1450-R1456, 1989;
0363-6119/89 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 257, Issue 6 1450-R1456, Copyright © 1989 by American Physiological Society

ARTICLES

Excitatory effect of substance P in parasympathetic ganglia of cat urinary bladder

M. Kawatani, T. Whitney, A. M. Booth and W. C. de Groat
Department of Pharmacology, University of Pittsburgh School of Medicine, Pennsylvania 15261.

Intra-arterial administration of substance P (0.1-50 micrograms/kg) to the urinary bladder of the cat produced slow-onset and sustained bladder contractions, asynchronous firing of bladder postganglionic nerves, and facilitation of nicotinic transmission in bladder ganglia. Intracellular recording from bladder ganglia in vitro revealed that substance P depolarized ganglion cells and initiated burst of action potentials (maximal frequency 6-7 Hz). The ganglionic excitatory effect of substance P in situ was blocked by gamma-aminobutyric acid (2-20 micrograms/kg) and the substance P antagonist [D-Arg1,D-Pro2,D-Trp7.9,Leu11]substance P (0.5-20 micrograms/kg) but was not altered by atropine (10-100 micrograms/kg), hexamethonium (0.5-2 mg/kg), norepinephrine (2-20 micrograms/kg), or leucine enkephalin (0.5-20 micrograms/kg). The bladder contractions elicited by substance P were not blocked by atropine, hexamethonium, or [D-Arg1,D-Pro2,D-Trp7.9,Leu11]substance P (0.1-10 micrograms/kg) but were blocked by another substance P antagonist, [D-Pro2,D-Phe7,D-Trp9]substance P. These data indicate that substance P has a direct postsynaptic excitatory effect on neurons in the vesical parasympathetic ganglia and on bladder smooth muscle cells. The differential effects of substance P antagonists on the excitatory responses at these two sites indicate the responses were mediated by different types of tachykinin receptors.


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L. Zhang, J. D. Tompkins, J. C. Hancock, and D. B. Hoover
Substance P modulates nicotinic responses of intracardiac neurons to acetylcholine in the guinea pig
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R1792 - R1800.
[Abstract] [Full Text] [PDF]


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