AJP - Regulatory, Integrative and Comparative Physiology, Vol 257, Issue 6 1474-R1480, Copyright © 1989 by American Physiological Society

ARTICLES

Effect of hepatic portal glucose concentration on food intake and metabolism

M. G. Tordoff, J. P. Tluczek and M. I. Friedman
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104.

To examine the effect of different hepatic portal glucose concentrations on food intake and metabolism, rats were given hepatic portal or jugular infusions (83 microliters/min for 2 h) of 0.3, 0.6, and 1.2 M glucose, equiosmotic NaCl, or a mock control infusion. Food intake was decreased to the same extent by the three concentrations of glucose infused into the hepatic portal vein and unaffected by any concentration of glucose infused into the jugular vein. Parallel to the changes in food intake, hepatic glycogen content was increased by glucose infused into the hepatic portal vein but not jugular vein. Conversely, systemic plasma glucose levels were increased by glucose infused into the jugular vein but not hepatic portal vein. Plasma insulin levels increased to the same extent irrespective of the route of infusion. Food intake was unaffected by the osmolarity of glucose infused into the hepatic portal vein, but was decreased by hyperosmotic NaCl control infusions. Hyperosmotic NaCl infusions also elevated levels of circulating fat fuels, indicating a stress response. The results show that the critical metabolic event in the liver that influences food intake is only indirectly coupled to the concentration of glucose in the hepatic portal vein.

This article has been cited by other articles:

				G. N. Wade and J. E. Jones Neuroendocrinology of nutritional infertility Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1277 - R1296. [Abstract] [Full Text] [PDF]

				J. Zhou, M. Xia Shi, T. D. Mitchell, G. N. Smagin, S. R. Thomas, D. H. Ryan, and R. B.S. Harris Changes in Rat Adipocyte and Liver Glucose Metabolism Following Repeated Restraint Stress Experimental Biology and Medicine, April 1, 2001; 226(4): 312 - 319. [Abstract] [Full Text]

				P.-O. Carlsson, M. Iwase, and L. Jansson Intraportal glucose infusion and pancreatic islet blood flow in anesthetized rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1224 - R1229. [Abstract] [Full Text] [PDF]

				C. J. Silberbauer, D. M. Surina-Baumgartner, M. Arnold, and W. Langhans Prandial lactate infusion inhibits spontaneous feeding in rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2000; 278(3): R646 - R653. [Abstract] [Full Text] [PDF]

				S. Cardin, M. Emshwiller, P. A. Jackson, W. L. Snead, J. Hastings, D. S. Edgerton, and A. D. Cherrington Portal glucose infusion increases hepatic glycogen deposition in conscious unrestrained rats J Appl Physiol, October 1, 1999; 87(4): 1470 - 1475. [Abstract] [Full Text] [PDF]

				J.-P. Baird, H. J. Grill, and J. M. Kaplan Effect of hepatic glucose infusion on glucose intake and licking microstructure in deprived and nondeprived rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1999; 277(4): R1136 - R1143. [Abstract] [Full Text] [PDF]