AJP - Regu Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 258: R104-R111, 1990;
0363-6119/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wallace, M. J.
Right arrow Articles by Harding, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wallace, M. J.
Right arrow Articles by Harding, R.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 258, Issue 1 104-R111, Copyright © 1990 by American Physiological Society

ARTICLES

Regulation of lung liquid secretion by arginine vasopressin in fetal sheep

M. J. Wallace, S. B. Hooper and R. Harding
Department of Physiology, Monash University, Melbourne, Victoria, Australia.

We have investigated the influence of gestational age on the inhibition of fetal lung liquid secretion by arginine vasopressin (AVP). In eight fetal sheep, lung liquid secretion rates were measured before and during infusion of AVP (300 mu.kg-1.h-1) at gestational ages between 110 and 148 days. During infusions, the concentration of AVP in fetal plasma increased from less than 8.7 +/- 0.2 pg/ml to 848.7 +/- 75.1 pg/ml. Fetal plasma epinephrine concentrations were not altered during AVP infusion. Infusions of AVP had no effect on fetal lung secretion before 135 days of gestation; they caused a 40.8% inhibition between 136 and 140 days, and at ages greater than 140 days induced an inhibition of 78.4%. In two ewes during labor, AVP infusion caused either a complete inhibition of secretion or reabsorption of lung liquid. The inhibitory effect of AVP increased in an exponential-like fashion with increasing gestational age and appeared to parallel the preparturient rise in fetal plasma cortisol concentrations. Our results indicate that AVP may be involved in the clearance of lung liquid at term and that AVP is unlikely to mediate the inhibitory effect of fetal asphyxia on lung liquid secretion, at least until after 135 days of gestation.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. L. Siew, M. J. Wallace, M. J. Kitchen, R. A. Lewis, A. Fouras, A. B. te Pas, N. Yagi, K. Uesugi, K. K. W. Siu, and S. B. Hooper
Inspiration regulates the rate and temporal pattern of lung liquid clearance and lung aeration at birth
J Appl Physiol, June 1, 2009; 106(6): 1888 - 1895.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. L. Siew, A. B. te Pas, M. J. Wallace, M. J. Kitchen, R. A. Lewis, A. Fouras, C. J. Morley, P. G. Davis, N. Yagi, K. Uesugi, et al.
Positive end-expiratory pressure enhances development of a functional residual capacity in preterm rabbits ventilated from birth
J Appl Physiol, May 1, 2009; 106(5): 1487 - 1493.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. D. Bland
Loss of liquid from the lung lumen in labor: more than a simple "squeeze"
Am J Physiol Lung Cell Mol Physiol, April 1, 2001; 280(4): L602 - L605.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Lines, S. B. Hooper, and R. Harding
Lung liquid production rates and volumes do not decrease before labor in healthy fetal sheep
J Appl Physiol, March 1, 1997; 82(3): 927 - 932.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online