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Am J Physiol Regul Integr Comp Physiol 258: R274-R280, 1990;
0363-6119/90 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 258, Issue 1 274-R280, Copyright © 1990 by American Physiological Society

ARTICLES

Computer-assisted long-term measurements of urinary output and other biological data

H. W. Reinhardt, U. Palm, R. Mohnhaupt, K. Dannenberg and W. Boemke
Experimental Anesthesia, Free University of Berlin, Universitatsklinikum Rudolf-Virchow-Charlottenburg, Federal Republic of Germany.

A computerized system is described, combining automatic collection of urine in short intervals (minutes) over long periods (days) and recordings of body temperature, MABP, and heart rate in chronically instrumented conscious dogs. During the studies the dogs are housed in metabolic cages. Indwelling catheters and electrical wires are connected to a specially designed swivel and directed out of the cage to the next room. Infusions, blood sampling, and monitoring can be performed from this room without disturbance to the dogs. Three examples of recordings are given. In one of these examples the sodium excretion patterns on 5 consecutive days under continuous saline infusion in one dog is evaluated. Urine was collected every 20 min. Sodium excretion showed cyclic variations. Fourier analysis exhibited 18-h periods and 4- to 8-h periods. The described system renders, e.g., coherent time series analysis possible for a variety of simultaneously recorded physiological variables and may thus acquire considerable importance for integrative physiology.


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