AJP - Regulatory, Integrative and Comparative Physiology, Vol 258, Issue 1 94-R98, Copyright © 1990 by American Physiological Society

ARTICLES

Effect of vasopressin on production of cerebrospinal fluid: possible role of vasopressin (V1)-receptors

F. M. Faraci, W. G. Mayhan and D. D. Heistad
Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, Iowa.

The goal of this study was to examine the role of arginine vasopressin in humoral regulation of choroid plexus function. Production of cerebrospinal fluid (CSF) was measured in anesthetized rabbits with an indicator dilution method, by using ventriculocisternal perfusion of artificial CSF containing blue dextran. Rabbits received either vehicle, vasopressin or vasopressin in the presence of the V1-antagonist [1-(beta-mercapto-beta,beta-cyclopentamethylene propionic acid), 2-(O-methyl)tyrosine]arginine vasopressin ([d(CH2)5Tyr(Me)]-AVP). Under control conditions, blood flow to the choroid plexus (measured with microspheres) averaged 369 +/- 26 (mean +/- SE) ml.min-1.100 g-1 and CSF production averaged 9.9 +/- 0.9 microliters/min. Intravenous infusion of vasopressin (2 mU.kg-1.min-1 for 90 min) decreased blood flow to the choroid plexus by 50-60% for the entire period of infusion. Vasopressin decreased production of CSF by 35 +/- 8%. Blood flow to the choroid plexus and production of CSF did not change significantly from control values in animals that received vehicle. In the presence of the V1-antagonist (10 micrograms/kg), infusion of vasopressin had no effect on blood flow to the choroid plexus or production of CSF. Thus circulating vasopressin, at plasma levels that are observed under physiological and pathophysiological conditions, has important effects on formation of CSF, as well as on blood flow to the choroid plexus. These findings are consistent with the hypothesis that effects of vasopressin on both variables are mediated through vasopressin (V1)-receptors.

This article has been cited by other articles:

				C. E. Johanson, J. Szmydynger-Chodobska, A. Chodobski, A. Baird, P. McMillan, and E. G. Stopa Altered formation and bulk absorption of cerebrospinal fluid in FGF-2-induced hydrocephalus Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R263 - R271. [Abstract] [Full Text] [PDF]

				M. Burnatowska-Hledin, I. B. Lazdins, L. Listenberger, P. Zhao, A. Sharangpani, V. Folta, and B. Card VACM-1 receptor is specifically expressed in rabbit vascular endothelium and renal collecting tubule Am J Physiol Renal Physiol, February 1, 1999; 276(2): F199 - F209. [Abstract] [Full Text] [PDF]

				C. E. Johanson, J. E. Preston, A. Chodobski, E. G. Stopa, J. Szmydynger-Chodobska, and P. N. McMillan AVP V1 receptor-mediated decrease in Cl- efflux and increase in dark cell number in choroid plexus epithelium Am J Physiol Cell Physiol, January 1, 1999; 276(1): C82 - C90. [Abstract] [Full Text] [PDF]

				A. Chodobski, J. Szmydynger-Chodobska, and M. J. McKinley Cerebrospinal fluid formation and absorption in dehydrated sheep Am J Physiol Renal Physiol, August 1, 1998; 275(2): F235 - F238. [Abstract] [Full Text] [PDF]

				E. A. Eldredge, M. A. Rockoff, M. D. Medlock, R. M. Scott, and M. B. Millis Postoperative Cerebral Edema Occurring in Children With Slit Ventricles Pediatrics, April 1, 1997; 99(4): 625 - 625. [Full Text] [PDF]