AJP - Regulatory, Integrative and Comparative Physiology, Vol 258, Issue 2 531-R535, Copyright © 1990 by American Physiological Society

ARTICLES

Regulation of plasma atrial natriuretic peptide by the central nervous system

A. L. Rauch, M. F. Callahan, V. M. Buckalew Jr and M. Morris
Department of Medicine/Nephrology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.

The anterior ventral region of the third ventricle (AV3V) is a major central site in the regulation of cardiovascular and renal function. To examine the role of the central nervous system in the regulation of atrial natriuretic peptide (ANP) secretion, the effect of lesions in this region on basal, volume-stimulated, and osmotic-stimulated plasma ANP was determined. Basal levels of plasma ANP were not different in sham- and AV3V-lesioned rats. Volume expansion with a continuous infusion of saline or with a bolus administration of saline increased plasma ANP in sham-lesioned rats. In AV3V-lesioned rats, continuous infusion of saline had no effect on plasma ANP, and a bolus administration of saline decreased plasma ANP. Osmotic stimulation with hypertonic saline increased plasma ANP in sham-lesioned rats but had no effect on plasma ANP in AV3V-lesioned rats. These results suggest that the central nervous system is involved in the regulation of ANP secretion and that altered ANP regulation may contribute to the cardiovascular and renal deficiencies in AV3V-lesioned rats.

This article has been cited by other articles:

				J. ANTUNES-RODRIGUES, M. DE CASTRO, L. L. K. ELIAS, M. M. VALENCA, and S. M. McCANN Neuroendocrine Control of Body Fluid Metabolism Physiol Rev, January 1, 2004; 84(1): 169 - 208. [Abstract] [Full Text] [PDF]

				D. S. A. Colombari and S. L. Cravo Effects of Acute AV3V Lesions on Renal and Hindlimb Vasodilation Induced by Volume Expansion Hypertension, October 1, 1999; 34(4): 762 - 767. [Abstract] [Full Text] [PDF]