AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 258: R958-R972, 1990;
0363-6119/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Seames, E. L.
Right arrow Articles by Popovich, R. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seames, E. L.
Right arrow Articles by Popovich, R. P.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 258, Issue 4 958-R972, Copyright © 1990 by American Physiological Society

ARTICLES

A distributed model of fluid and mass transfer in peritoneal dialysis

E. L. Seames, J. W. Moncrief and R. P. Popovich
Department of Chemical Engineering, University of Texas, Austin 78712.

A mathematical model has been developed to study peritoneal fluid and solute transfer. The model uses the concept of a distributed capillary system within the peritoneal tissue. The model accounts explicitly for transport across the capillary membrane, through interstitial tissue, and across the mesothelium. The capillary and mesothelial membranes are modeled using pore theory and a dual pathway (through pores and across cells) for fluid transfer. The nonperitoneal tissues are modeled as a single body pool. Lymphatic uptake from the peritoneal cavity is included. Model parameters were found from the literature and by simultaneously fitting experimental data for dialysate volume and dialysate concentrations of blood urea nitrogen, glucose, creatinine, and inulin. The model was also shown to predict concentration gradients within several tissues surrounding the peritoneal cavity. Variation of the model parameters revealed the importance of the mesothelial cell layer in peritoneal ultrafiltration. The results of model simulations indicate an initial transfer of fluid from the tissue space to the peritoneal cavity followed by transcapillary fluid transfer.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Stachowska-Pietka, J. Waniewski, M. F. Flessner, and B. Lindholm
Distributed model of peritoneal fluid absorption
Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1862 - H1874.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. F. Flessner
Transport of protein in the abdominal wall during intraperitoneal therapy. I. Theoretical approach
Am J Physiol Gastrointest Liver Physiol, August 1, 2001; 281(2): G424 - G437.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. Venturoli and B. Rippe
Transport asymmetry in peritoneal dialysis: application of a serial heteroporous peritoneal membrane model
Am J Physiol Renal Physiol, April 1, 2001; 280(4): F599 - F606.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
H. DEMISSACHEW, J. LOFTHOUSE, and M. F. FLESSNER
Tissue Sources and Blood Flow Limitations of Osmotic Water Transport Across the Peritoneum
J. Am. Soc. Nephrol., February 1, 1999; 10(2): 347 - 353.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online