AJP - Regulatory, Integrative and Comparative Physiology, Vol 259, Issue 4 716-R723, Copyright © 1990 by American Physiological Society

ARTICLES

Effect of dietary limiting amino acid in prepyriform cortex on meal patterns

J. L. Beverly, D. W. Gietzen and Q. R. Rogers
Department of Physiological Sciences, School of Veterinary Medicine, University of California, Davis 95616.

Microinjection of the dietary limiting essential amino acid (DLAA) into the prepyriform cortex (PPC) increased intake of a diet having an imbalance among the essential amino acids (imbalanced diet) from 50-55% of baseline, when artificial cerebrospinal fluid (aCSF) was injected, to 70-75% of baseline. The increase in intake of the imbalanced diet by DLAA injection became apparent after 3-6 h and was maintained throughout the dark period. Meal size, meal duration, and the number of meals returned to normal after bilateral injections of the DLAA into the PPC of rats fed the imbalanced diet. Injection of the DLAA 30 min before the onset of the dark phase increased intake of imbalanced diet to 70% of baseline intake. When injections of threonine or isoleucine were made 6 and 3 h, respectively, prior to onset of the dark phase, intake of imbalanced diet increased to 85% of baseline intake. Results suggest that some form of processing of the injected DLAA within the PPC is necessary to increase the intake of imbalanced diets.

This article has been cited by other articles:

				D. W. Gietzen and L. J. Magrum Molecular Mechanisms in the Brain Involved in the Anorexia of Branched-Chain Amino Acid Deficiency J. Nutr., March 1, 2001; 131(3): 851S - 855. [Abstract] [Full Text]

				P. C. Even, V. Rolland, S. Feurte, G. Fromentin, S. Roseau, S. Nicolaidis, and D. Tome Postprandial metabolism and aversive response in rats fed a threonine-devoid diet Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R248 - R254. [Abstract] [Full Text] [PDF]

				C. X. Wang, L. F. Erecius, J. L. Beverly III, and D. W. Gietzen Essential Amino Acids Affect Interstitial Dopamine Metabolites in the Anterior Piriform Cortex of Rats J. Nutr., September 1, 1999; 129(9): 1742 - 1745. [Abstract] [Full Text]

				L. L. Bellinger, J. F. Evans, C. M. Tillberg, and D. W. Gietzen Effects of dorsomedial hypothalamic nuclei lesions on intake of an imbalanced amino acid diet Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R250 - R262. [Abstract] [Full Text] [PDF]

				T. A. Houpt and R. Berlin Rapid, Labile, and Protein Synthesis- Independent Short-Term Memory in Conditioned Taste Aversion Learn. Mem., January 1, 1999; 6(1): 37 - 46. [Abstract] [Full Text]

				L. L. Bellinger, J. F. Evans, and D. W. Gietzen Dorsomedial Hypothalamic Lesions Alter Intake of an Imbalanced Amino Acid Diet in Rats J. Nutr., July 1, 1998; 128(7): 1213 - 1217. [Abstract] [Full Text] [PDF]