AJP - Regulatory, Integrative and Comparative Physiology, Vol 259, Issue 4 729-R735, Copyright © 1990 by American Physiological Society

ARTICLES

Angiotensin and salt appetite of BALB/c mice

D. A. Denton, J. R. Blair-West, M. McBurnie, P. G. Osborne, E. Tarjan, R. M. Williams and R. S. Weisinger
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.

The influence of systemic or intracerebroventricular (icv) administration of angiotensin II on the intakes of NaCl solution, water, and food was investigated in BALB/c mice. Systemic administration of angiotensin II had little, if any, influence on these ingestive behaviors. On the other hand, icv infusion of angiotensin II at 70 ng/day increased (P less than 0.05) intakes of NaCl solution and water by the third day of infusion. The amount of NaCl ingested daily during the infusion was two to three times body sodium content. The mean daily water intake increased to 40-60% of body weight. The vast increase in NaCl intake was not secondary to a natriuresis caused by the icv infusion of angiotensin II. The results suggest that angiotensin II has a direct effect on neural systems involved in sodium appetite in this species.

This article has been cited by other articles:

				J. C. Geerling and A. D. Loewy Central regulation of sodium appetite Exp Physiol, February 1, 2008; 93(2): 177 - 209. [Abstract] [Full Text] [PDF]

				E. C. Crews and N. E. Rowland Role of angiotensin in body fluid homeostasis of mice: effect of losartan on water and NaCl intakes Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R638 - R644. [Abstract] [Full Text] [PDF]

				R. F. Johnson, T. G. Beltz, R. L. Thunhorst, and A. K. Johnson Investigations on the physiological controls of water and saline intake in C57BL/6 mice Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R394 - R403. [Abstract] [Full Text] [PDF]

				O. Skott Angiotensin II and control of sodium and water intake in the mouse Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1380 - R1381. [Full Text] [PDF]

				N. E. Rowland, B. E. Goldstein, and K. L. Robertson Role of angiotensin in body fluid homeostasis of mice: fluid intake, plasma hormones, and brain Fos Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1586 - R1594. [Abstract] [Full Text] [PDF]

				R. S. Weisinger, J. R. Blair-West, P. Burns, D. A. Denton, and B. Purcell Cerebral Na concentration, Na appetite and thirst of sheep: influence of somatostatin and losartan Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2001; 280(3): R686 - R694. [Abstract] [Full Text] [PDF]

				D. A. Denton, J. R. Blair-West, M. I. McBurnie, J. A. P. Miller, R. S. Weisinger, and R. M. Williams Effect of adrenocorticotrophic hormone on sodium appetite in mice Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1999; 277(4): R1033 - R1040. [Abstract] [Full Text] [PDF]

				J. R. Blair-West, K. D. Carey, D. A. Denton, R. S. Weisinger, and R. E. Shade Evidence that brain angiotensin II is involved in both thirst and sodium appetite in baboons Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1639 - R1646. [Abstract] [Full Text] [PDF]

				J. M. Sweeny, H. E. Seibert, C. Woda, J. Schulkin, A. Haramati, and S. E. Mulroney Evidence for induction of a phosphate appetite in juvenile rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R1358 - R1365. [Abstract] [Full Text] [PDF]

				J. T. FITZSIMONS Angiotensin, Thirst, and Sodium Appetite Physiol Rev, July 1, 1998; 78(3): 583 - 686. [Abstract] [Full Text] [PDF]

				J. L. Halaas, C. Boozer, J. Blair-West, N. Fidahusein, D. A. Denton, and J. M. Friedman Physiological response to long-term peripheral and central leptin infusion in lean and obese mice PNAS, August 5, 1997; 94(16): 8878 - 8883. [Abstract] [Full Text] [PDF]