AJP - Regulatory, Integrative and Comparative Physiology, Vol 259, Issue 6 1189-R1197, Copyright © 1990 by American Physiological Society

ARTICLES

Entrainment of circadian rhythms with 26-h bright light and sleep-wake schedules

C. I. Eastman and K. J. Miescke
Biological Rhythms Research Laboratory, Rush-Presbyterian-St. Luke's Medical Center, Chicago 60612.

Subjects followed a 26-h sleep-wake schedule and were exposed to various light patterns while living at home exposed to the conflicting 24-h zeitgebers. In one protocol, a 26-h light pattern containing evening bright light was compared with a natural-light-only pattern. In another protocol, the evening-light pattern was compared with a morning-light pattern. Rectal temperature was continuously measured. Sleep times were estimated from daily sleep logs. The sleep times of most subjects conformed fairly well to the 26-h sleep-wake schedule, although the evening-light condition produced slightly better results. A larger proportion of subjects had their temperature rhythm entrained to the 26-h schedule during the evening-light condition than during the morning-light or natural-light conditions. Entrainment to the 26-h schedule was achieved in 74% (14/19) of the subjects tested in the evening-light condition. This study shows that non-24-h bright light and sleep-wake schedules can be used to phase shift and entrain human circadian rhythms, despite the presence of the conflicting 24-h zeitgebers.

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				K. P. Wright Jr., R. J Hughes, R. E. Kronauer, D.-J. Dijk, and C. A. Czeisler Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans PNAS, November 20, 2001; 98(24): 14027 - 14032. [Abstract] [Full Text] [PDF]