AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 260: R263-R266, 1991;
0363-6119/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ladenheim, E. E.
Right arrow Articles by Ritter, R. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ladenheim, E. E.
Right arrow Articles by Ritter, R. C.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 260, Issue 2 263-R266, Copyright © 1991 by American Physiological Society

ARTICLES

Capsaicin attenuates bombesin-induced suppression of food intake

E. E. Ladenheim and R. C. Ritter
Department of Veterinary and Comparative Anatomy, Washington State University, Pullman 99164.

This study was conducted to evaluate the extent to which bombesin (BBS)-induced suppression of food intake relies on small, unmyelinated sensory neurons. Rats were pretreated intraperitoneally with capsaicin, a neurotoxin that destroys a subpopulation of small-diameter sensory neurons, and tested for suppression of food intake after intraperitoneal administration of 2, 4, 8, 16, and 32 micrograms/kg BBS. Capsaicin pretreatment attenuated suppression of food intake by BBS over a wide range of doses. The site of capsaicin action was not determined in this study. However, work by others indicates that vagal and nonvagal neural substrates participate in suppression of food intake by BBS. Afferents of both of these substrates are predominantly small and unmyelinated. Therefore, the deficits in BBS-induced suppression of food intake that we observed may reflect damage to both vagal and/or nonvagal neurons that participate in BBS-induced suppression of food intake.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Riediger, H. A. Schmid, T. Lutz, and E. Simon
Amylin potently activates AP neurons possibly via formation of the excitatory second messenger cGMP
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R1833 - R1843.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Michaud, H. Anisman, and Z. Merali
Capsaicin-sensitive fibers are required for the anorexic action of systemic but not central bombesin
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1617 - R1622.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. A. Lutz, J. Althaus, R. Rossi, and E. Scharrer
Anorectic effect of amylin is not transmitted by capsaicin-sensitive nerve fibers
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1998; 274(6): R1777 - R1782.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. Karlsson, F. Sundler, and B. Ahren
Insulin secretion by gastrin-releasing peptide in mice: ganglionic versus direct islet effect
Am J Physiol Endocrinol Metab, January 1, 1998; 274(1): E124 - E129.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online