AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 260: R441-R447, 1991;
0363-6119/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brown, J.
Right arrow Articles by Czarnecki, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brown, J.
Right arrow Articles by Czarnecki, A.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 260, Issue 2 441-R447, Copyright © 1991 by American Physiological Society

ARTICLES

Receptor subtypes for natriuretic peptides in the brains of hypertensive rats

J. Brown and A. Czarnecki
Physiological Laboratory, Cambridge, United Kingdom.

Receptor subtypes for alpha-atrial natriuretic peptide (alpha-ANP) were characterized in brains of 12-wk-old Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) by in vitro autoradiography, using des[Gln18, Ser19,Gly20,Leu21,Gly22]ANP-(4-23) (C-ANP) and ANP-(5-25) as subtype-selective ligands. 125I-labeled alpha-ANP (200 pM) bound reversibly to arachnoid mater (AM), choroid plexus (ChP), subfornical organ (SFO), median preoptic nucleus, and supraoptic nucleus. Apparent Kd values for alpha-ANP in AM, ChP, and SFO were 1-6 nM and they were lowest in SHR. Maximal binding capacities for alpha-ANP on ChP and SFO were also significantly lower in SHR, and 10 microM C-ANP or 10 microM ANP-(5-25) inhibited most radioligand binding on AM of WKY and SHR. C-ANP significantly inhibited no other alpha-125I-ANP binding. ANP-(5-25) was a relatively weak inhibitor of alpha-125I-ANP binding to ChP and SFO in WKY but it was powerful in SHR. The results suggest that AM expresses clearance receptor for alpha-ANP in WKY and SHR. Other structures do not express this receptor significantly but express two other receptors for alpha-ANP, one mainly in WKY and one mainly in SHR.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
H. E. De Wardener
The Hypothalamus and Hypertension
Physiol Rev, October 1, 2001; 81(4): 1599 - 1658.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online