AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 260: R906-R910, 1991;
0363-6119/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bernstein, I. L.
Right arrow Articles by Bentson, K. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bernstein, I. L.
Right arrow Articles by Bentson, K. L.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 260, Issue 5 906-R910, Copyright © 1991 by American Physiological Society

ARTICLES

TNF-induced anorexia and learned food aversions are attenuated by area postrema lesions

I. L. Bernstein, E. M. Taylor and K. L. Bentson
Department of Psychology, University of Washington, Seattle 98195.

Tumor necrosis factor (TNF) or cachectin has been proposed as an important mediator of cancer anorexia and cachexia. The present studies examined the extent to which TNF administration generates symptoms similar to those produced by tumor growth. Like the growth of certain tumors, TNF administration was found to be associated with the development of strong aversions to a novel diet. Area postrema lesions were found to significantly attenuate the effects of TNF on intake of a novel diet, a finding previously reported for tumor anorexia. In addition, the anorexic effects of TNF differed considerably as a function of the novelty of the diet. When the available diet was novel, effects of TNF in lowering food intake were substantial, whereas more modest effects were seen when the diet was familiar. These findings provide evidence for parallels between TNF- and tumor-induced anorexias. Nonetheless, these studies also confirm previous observations of the rapid development of tolerance to the anorexic effects of TNF, a finding that is not consistent with a role for TNF as a critical mediator of tumor anorexia.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Kubota, J. Fang, Z. Guan, R. A. Brown, and J. M. Krueger
Vagotomy attenuates tumor necrosis factor-{alpha}-induced sleep and EEG {delta}-activity in rats
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1213 - R1220.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. K. Cross-Mellor, W. D. T. Kent, K.-P. Ossenkopp, and M. Kavaliers
Differential effects of lipopolysaccharide and cholecystokinin on sucrose intake and palatability
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 1999; 277(3): R705 - R715.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online