AJP - Regu AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 261: R427-R433, 1991;
0363-6119/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Soltis, R. P.
Right arrow Articles by DiMicco, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Soltis, R. P.
Right arrow Articles by DiMicco, J. A.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 261, Issue 2 427-R433, Copyright © 1991 by American Physiological Society

ARTICLES

Interaction of hypothalamic GABAA and excitatory amino acid receptors controlling heart rate in rats

R. P. Soltis and J. A. DiMicco
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202.

We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to stress. The purpose of this study was to examine the role of excitatory amino acid (EAA) receptors in the DMH in generating the cardiovascular changes caused by withdrawal of local GABAergic inhibition in urethan-anesthetized rats. Local treatment of the DMH with the nonselective EAA antagonist kynurenic acid blocked or reversed the increases in heart rate and blood pressure caused by microinjection of the GABAA antagonists bicuculline methiodide (BMI) or picrotoxin into the same region. Conversely, similar injection of xanthurenic acid, a structural analogue of kynurenic acid without significant effects on EAA receptors, did not significantly alter the cardiovascular changes produced by either GABAA antagonist. The tachycardic effects of BMI were also attenuated by injection of either the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphonopentanoic acid or the non-NMDA EAA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione. When the two EAA receptor antagonists were combined, their effects to suppress the BMI-induced tachycardia were additive. These findings suggest that the cardiovascular effects caused by blockade of GABAergic inhibition in the DMH of the rat are dependent on activation of local NMDA and non-NMDA EAA receptors.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. De Matteo, G. A. Head, and D. N. Mayorov
Angiotensin II in dorsomedial hypothalamus modulates cardiovascular arousal caused by stress but not feeding in rabbits
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R257 - R264.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. C. Samuels, D. V. Zaretsky, and J. A. DiMicco
Dorsomedial hypothalamic sites where disinhibition evokes tachycardia correlate with location of raphe-projecting neurons
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R472 - R478.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. J. Madden and S. F. Morrison
Excitatory amino acid receptors in the dorsomedial hypothalamus mediate prostaglandin-evoked thermogenesis in brown adipose tissue
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2004; 286(2): R320 - R325.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. A. P. Fontes, T. Tagawa, J. W. Polson, S.-J. Cavanagh, and R. A. L. Dampney
Descending pathways mediating cardiovascular response from dorsomedial hypothalamic nucleus
Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2891 - H2901.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. W. Bailey and J. A. Dimicco
Chemical stimulation of the dorsomedial hypothalamus elevates plasma ACTH in conscious rats
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2001; 280(1): R8 - R15.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. P. Soltis, J. C. Cook, A. E. Gregg, J. M. Stratton, and K. A. Flickinger
EAA receptors in the dorsomedial hypothalamic area mediate the cardiovascular response to activation of the amygdala
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1998; 275(2): R624 - R631.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. P. Soltis, J. C. Cook, A. E. Gregg, and B. J. Sanders
Interaction of GABA and Excitatory Amino Acids in the Basolateral Amygdala: Role in Cardiovascular Regulation
J. Neurosci., December 1, 1997; 17(23): 9367 - 9374.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Sadamoto and K. Matsukawa
Cardiovascular responses during spontaneous overground locomotion in freely moving decerebrate cats
J Appl Physiol, November 1, 1997; 83(5): 1454 - 1460.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online