AJP - Regulatory, Integrative and Comparative Physiology, Vol 261, Issue 3 690-R696, Copyright © 1991 by American Physiological Society

ARTICLES

Effects of intravenous infusions of angiotensin II on muscle sympathetic nerve activity in humans

T. Matsukawa, E. Gotoh, K. Minamisawa, M. Kihara, S. Ueda, H. Shionoiri and M. Ishii
Second Department of Internal Medicine, Yokohama City University School of Medicine, Japan.

The effect of angiotensin II (ANG II) on the sympathetic outflow was examined in normal humans. The mean arterial pressure and muscle sympathetic nerve activity (MSNA) were measured before and during intravenous infusions of phenylephrine (0.5 and 1.0 micrograms.kg-1.min-1) or ANG II (5, 10, and 20 ng.kg-1.min-1) for 15 min at 30-min intervals. The baroreflex slope for the relationship between the increases in mean arterial pressure and the reductions in MSNA was significantly less acute during the infusions of ANG II than during the infusions of phenylephrine. When nitroprusside was infused simultaneously to maintain central venous pressure at the basal level, MSNA significantly increased during the infusions of ANG II (5 ng.kg-1.min-1 for 15 min) but not during the infusions of phenylephrine (1.0 micrograms.kg-1.min-1 for 15 min), with accompanying attenuation of the elevation in arterial pressure induced by these pressor agents. These findings suggest that ANG II stimulates the sympathetic outflow without mediating baroreceptor reflexes in humans.

This article has been cited by other articles:

				S. McMullan, A. K. Goodchild, and P. M. Pilowsky Circulating angiotensin II attenuates the sympathetic baroreflex by reducing the barosensitivity of medullary cardiovascular neurones in the rat J. Physiol., July 15, 2007; 582(2): 711 - 722. [Abstract] [Full Text] [PDF]

				Q. Fu, R. P. Shook, K. Okazaki, J. L. Hastings, S. Shibata, C. L. Conner, M. D. Palmer, and B. D. Levine Vasomotor sympathetic neural control is maintained during sustained upright posture in humans J. Physiol., December 1, 2006; 577(2): 679 - 687. [Abstract] [Full Text] [PDF]

				G. E. Alvarez, T. P. Ballard, S. D. Beske, and K. P. Davy Subcutaneous obesity is not associated with sympathetic neural activation Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H414 - H418. [Abstract] [Full Text] [PDF]

				K. P. Davy and J. E. Hall Obesity and hypertension: two epidemics or one? Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2004; 286(5): R803 - R813. [Abstract] [Full Text] [PDF]

				L. Xu and A. F. Sved Acute sympathoexcitatory action of angiotensin II in conscious baroreceptor-denervated rats Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R451 - R459. [Abstract] [Full Text] [PDF]

				I. H. H. T. KLEIN, G. LIGTENBERG, P. L. OEY, H. A. KOOMANS, and P. J. BLANKESTIJN Sympathetic Activity Is Increased in Polycystic Kidney Disease and Is Associated with Hypertension J. Am. Soc. Nephrol., November 1, 2001; 12(11): 2427 - 2433. [Abstract] [Full Text] [PDF]

				J. P. Greenwood, E. M. Scott, J. B. Stoker, J. J. Walker, and D. A.S.G. Mary Sympathetic Neural Mechanisms in Normal and Hypertensive Pregnancy in Humans Circulation, October 30, 2001; 104(18): 2200 - 2204. [Abstract] [Full Text] [PDF]

				M. Johansson, M. Elam, B. Rundqvist, G. Eisenhofer, H. Herlitz, G. Jensen, and P. Friberg Differentiated Response of the Sympathetic Nervous System to Angiotensin-Converting Enzyme Inhibition in Hypertension Hypertension, October 1, 2000; 36(4): 543 - 548. [Abstract] [Full Text] [PDF]

				T. Matsukawa, Y. Sugiyama, T. Watanabe, F. Kobayashi, and T. Mano Gender difference in age-related changes in muscle sympathetic nerve activity in healthy subjects Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1600 - R1604. [Abstract] [Full Text] [PDF]

				A. Nakata, S. Takata, T. Yuasa, A. Shimakura, M. Maruyama, H. Nagai, S. Sakagami, and K.-I. Kobayashi Spectral analysis of heart rate, arterial pressure, and muscle sympathetic nerve activity in normal humans Am J Physiol Heart Circ Physiol, April 1, 1998; 274(4): H1211 - H1217. [Abstract] [Full Text] [PDF]

				Q. Li, M. J. Sullivan, W. E. Dale, E. M. Hasser, E. H. Blaine, and J. T. Cunningham Fos-Like Immunoreactivity in the Medulla after Acute and Chronic Angiotensin II Infusion J. Pharmacol. Exp. Ther., March 1, 1998; 284(3): 1165 - 1173. [Abstract] [Full Text]

				G. Noll, R. R. Wenzel, S. de Marchi, S. Shaw, and T. F. Luscher Differential Effects of Captopril and Nitrates on Muscle Sympathetic Nerve Activity in Volunteers Circulation, May 6, 1997; 95(9): 2286 - 2292. [Abstract] [Full Text]

				M. Ming, J. Wu, S. Lachance, A. Delalandre, S. Carriere, and J. S. D. Chan ß-Adrenergic Receptors and Angiotensinogen Gene Expression in Mouse Hepatoma Cells In Vitro Hypertension, January 1, 1995; 25(1): 105 - 109. [Abstract] [Full Text]