AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 261: R1126-R1132, 1991;
0363-6119/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maktabi, M. A.
Right arrow Articles by Faraci, F. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maktabi, M. A.
Right arrow Articles by Faraci, F. M.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 261, Issue 5 1126-R1132, Copyright © 1991 by American Physiological Society

ARTICLES

Effects of central and intravascular angiotensin I and II on the choroid plexus

M. A. Maktabi, D. D. Heistad and F. M. Faraci
Department of Anesthesia, University of Iowa College of Medicine, Iowa City 52242.

The choroid plexus contains receptors for angiotensin II (ANG II) and a very high concentration of angiotensin-converting enzyme. The goal of this study was to test the hypothesis that central, as well as circulating, ANG I and II decrease blood flow to the choroid plexus. Under control conditions in anesthetized rabbits, blood flow (microspheres) to the choroid plexus was 449 +/- 21 (mean +/- SE) ml.min-1.100 g(-1). Intravascular ANG I (30 and 100 ng.kg-1.min-1) decreased blood flow to the choroid plexus by 19 +/- 14 and 28 +/- 18%, respectively. Intravascular ANG II (30 and 100 ng.kg-1.min-1) also produced a decrease in blood flow by 28 +/- 9 and 47 +/- 7%, respectively. When administered into the lateral ventricle, ANG I and II (10 and 100 ng.kg-1.min-1) decreased blood flow to a similar degree: 22 +/- 11 and 31 +/- 10% and 12 +/- 10 and 27 +/- 8%, respectively. Cerebral blood flow was not decreased by intravascular or central ANG I or II. The angiotensin-converting enzyme inhibitor quinaprilat prevented the decrease in blood flow to the choroid plexus in response to ANG I without affecting responses to ANG II. Thus 1) circulating ANG I and II are potent constrictors of blood vessels of the choroid plexus, 2) the constrictor effect of ANG I on the blood vessels of the choroid plexus appears mediated primarily by generation of ANG II, and 3) intracerebroventricular ANG I produces large reductions in the blood flow to the choroid plexus, which suggests that there is an effective central system that converts ANG I to ANG II.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
C. E. Johanson, J. E. Preston, A. Chodobski, E. G. Stopa, J. Szmydynger-Chodobska, and P. N. McMillan
AVP V1 receptor-mediated decrease in Cl- efflux and increase in dark cell number in choroid plexus epithelium
Am J Physiol Cell Physiol, January 1, 1999; 276(1): C82 - C90.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. A. Maktabi, M. M. Todd, and G. Stachovic
Angiotensin II Contributes to Cerebral Vasodilatation During Hypoxia in the Rabbit
Stroke, October 1, 1995; 26(10): 1871 - 1876.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online