AJP - Regu AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 261: R1214-R1217, 1991;
0363-6119/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wickler, S. J.
Right arrow Articles by van Breukelen, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wickler, S. J.
Right arrow Articles by van Breukelen, F.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 261, Issue 5 1214-R1217, Copyright © 1991 by American Physiological Society

ARTICLES

Disuse atrophy in the hibernating golden-mantled ground squirrel, Spermophilus lateralis

S. J. Wickler, D. F. Hoyt and F. van Breukelen
Department of Animal Science, California State Polytechnic University, Pomona 91768.

Disuse (inactivity, bed rest, and spaceflight) may lead to a loss of muscle mass and a decrease in oxidative capacity in skeletal muscle. If such changes were to occur in hibernating animals, both locomotor and thermogenic function would be compromised. Muscle masses and oxidative capacities (as assessed by citrate synthase activity) were measured in the gastrocnemius and semitendinosus muscles, cardiac muscle (ventricle), and brown fat (axillary pad) in a group (n = 7) of prehibernating ground squirrels (Spermophilus lateralis) and after 6 mo of hibernation (n = 8). Hibernation produced significant atrophy in the gastrocnemius (14%) and semitendinosus (42%) muscles. Cardiac tissue increased (21%) in mass, as did brown adipose tissue (150%). That such changes were not due simply to fluid shifts was evidenced by similar protein concentrations between groups. In contrast to many other disuse studies, oxidative capacity was increased significantly in the gastrocnemius (65%) and semitendinosus (37%). Citrate synthase was also higher in cardiac tissue of hibernators (20%) but was not significantly different in brown fat.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
B. C. Rourke, A. Qin, F. Haddad, K. M. Baldwin, and V. J. Caiozzo
Cloning and sequencing of myosin heavy chain isoform cDNAs in golden-mantled ground squirrels: effects of hibernation on mRNA expression
J Appl Physiol, November 1, 2004; 97(5): 1985 - 1991.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
H. V. CAREY, M. T. ANDREWS, and S. L. MARTIN
Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature
Physiol Rev, October 1, 2003; 83(4): 1153 - 1181.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
N. J. Hudson and C. E. Franklin
Maintaining muscle mass during extended disuse: aestivating frogs as a model species
J. Exp. Biol., August 1, 2002; 205(15): 2297 - 2303.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. van Breukelen and S. L. Martin
Molecular Biology of Thermoregulation: Invited Review: Molecular adaptations in mammalian hibernators: unique adaptations or generalized responses?
J Appl Physiol, June 1, 2002; 92(6): 2640 - 2647.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
D. Deveci and S. Egginton
Differing mechanisms of cold-induced changes in capillary supply in m. tibialis anterior of rats and hamsters
J. Exp. Biol., March 15, 2002; 205(6): 829 - 840.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online