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Am J Physiol Regul Integr Comp Physiol 261: R1276-R1285, 1991;
0363-6119/91 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 261, Issue 5 1276-R1285, Copyright © 1991 by American Physiological Society


ARTICLES

A model for the study of sexual function in anesthetized male and female rats

K. E. McKenna, S. K. Chung and K. T. McVary
Department of Physiology, Northwestern University School of Medicine, Chicago, Illinois 60611.

A preparation for the study of sexual function in anesthetized spinal male and female rats is discussed. Urethral stimulation in males elicited penile erection, ejaculation, and rhythmic contractions of the striated perineal muscles. In females, vaginal and uterine contractions and rhythmic contractions of the perineal muscles were elicited. These responses show many similarities to responses seen during sexual climax in unanesthetized humans and animals. This response, which we refer to as the urethrogenital reflex, is unaffected in either sex by gonadectomy. We determined that the urethrogenital reflex is produced by a spinal pattern generator and is under tonic descending inhibition from the brain stem. We conclude that this preparation may be a valuable model for experimental study of the neural mechanisms of sexual function in both sexes.


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