AJP - Regu Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 262: R216-R219, 1992;
0363-6119/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Miesner, J.
Right arrow Articles by Tyrka, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miesner, J.
Right arrow Articles by Tyrka, A.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 262, Issue 2 216-R219, Copyright © 1992 by American Physiological Society

ARTICLES

Intravenous infusion of CCKA-receptor antagonist increases food intake in rats

J. Miesner, G. P. Smith, J. Gibbs and A. Tyrka
Department of Psychiatry, Cornell University Medical College, White Plains, New York.

To test the hypothesis that endogenous cholecystokinin (CCK) released from the small intestine by ingested food produces a satiating effect by acting at CCKA-receptors, we measured the effect of slow continuous intravenous infusions of three doses of MK-329, a potent and selective CCKA-antagonist, on food intake during 2.5-h tests in 13 Sprague-Dawley male rats after 1 h of food deprivation. MK-329 increased food intake significantly and the lowest dose tested (0.5 mg.kg-1.h-1) produced the most consistent effect on cumulative intake. Part of the increased food intake under these conditions was due to a decrease in the satiating effect of food ingested at the first meal on the postprandial intermeal interval. These results are consistent with, but do not prove, the hypothesis that the satiating effect of endogenous CCK released from the small intestine by ingested food is mediated by CCKA-receptors.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. C. Woods
Gastrointestinal Satiety Signals I. An overview of gastrointestinal signals that influence food intake
Am J Physiol Gastrointest Liver Physiol, January 1, 2004; 286(1): G7 - G13.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
P. J. Havel
Peripheral Signals Conveying Metabolic Information to the Brain: Short-Term and Long-Term Regulation of Food Intake and Energy Homeostasis
Experimental Biology and Medicine, December 1, 2001; 226(11): 963 - 977.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Kelly, S. Morales, B. K. Smith, and H.-R. Berthoud
Capsaicin-treated rats permanently overingest low- but not high-concentration sucrose solutions
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2000; 279(5): R1805 - R1812.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. E. Cox
Cholecystokinin satiety involves CCKA receptors perfused by the superior pancreaticoduodenal artery
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1998; 274(5): R1390 - R1396.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online