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Am J Physiol Regul Integr Comp Physiol 262: R806-R812, 1992;
0363-6119/92 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 262, Issue 5 806-R812, Copyright © 1992 by American Physiological Society

ARTICLES

A method for identifying external control sites in metabolic systems

B. Crabtree
Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom.

A graphic method is presented for the identification of control sites in a metabolic system. This method is based on the matrix method for calculating net sensitivities developed by Crabtree and Newsholme (Biochem. J. 247: 113-120, 1987) and avoids the misidentification of control sites that can result from a simple inspection of a system. The method is easily adapted for analysis by computer and may be used for preliminary investigations of metabolic systems to identify potential control sites for further more quantitative investigations.




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