AJP - Regu Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 262: R1025-R1032, 1992;
0363-6119/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by West, D. B.
Right arrow Articles by Atkinson, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by West, D. B.
Right arrow Articles by Atkinson, R. L.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 262, Issue 6 1025-R1032, Copyright © 1992 by American Physiological Society

ARTICLES

Dietary obesity in nine inbred mouse strains

D. B. West, C. N. Boozer, D. L. Moody and R. L. Atkinson
Obesity, Diabetes, and Metabolism Section, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808.

The effect of 7 wk consumption of a diet containing 32.6% of kilocalories as fat [condensed milk (CM) diet] on body composition and energy intake was evaluated in nine strains of inbred mice (AKR/J, C57L/J, A/J, C3H/HeJ, DBA/2J, C57BL/6J, SJL/J, I/STN, and SWR/J). Control animals were fed a high-carbohydrate diet containing 11.6% of energy as fat (Purina Rodent Chow diet). Relative to Chow diet controls, the CM diet significantly increased carcass lipid content in six strains (AKR/J, C57L/J, A/J, C3H/HeJ, DBA/2J, and C57BL/6J), but had no or a marginal effect on adiposity in three strains of mice (SJL/J, I/STN, and SWR/J). The obesity produced by the CM diet in six strains was not due to hyperphagia. Only one of six (AKR/J) of the strains that increased adiposity on the CM diet consumed more energy than controls during the 7 wk of the experiment. The identification of inbred mouse strains that are sensitive to dietary obesity, vs. others that are resistant, provides a useful tool to pursue the metabolic and genetic basis of this trait in the mouse.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
V. Kus, T. Prazak, P. Brauner, M. Hensler, O. Kuda, P. Flachs, P. Janovska, D. Medrikova, M. Rossmeisl, Z. Jilkova, et al.
Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance
Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E356 - E367.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
C. Schmidt, N. P. Gonzaludo, S. Strunk, S. Dahm, J. Schuchhardt, F. Kleinjung, S. Wuschke, H.-G. Joost, and H. Al-Hasani
A meta-analysis of QTL for diabetes-related traits in rodents
Physiol Genomics, June 10, 2008; 34(1): 42 - 53.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. L. Svenson, R. Von Smith, P. A. Magnani, H. R. Suetin, B. Paigen, J. K. Naggert, R. Li, G. A. Churchill, and L. L. Peters
Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations
J Appl Physiol, June 1, 2007; 102(6): 2369 - 2378.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
A. Wagener, A. O. Schmitt, S. Aksu, W. Schlote, C. Neuschl, and G. A. Brockmann
Genetic, sex, and diet effects on body weight and obesity in the Berlin Fat Mouse Inbred lines
Physiol Genomics, November 21, 2006; 27(3): 264 - 270.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. K. Phan, W. K. Chung, and R. L. Leibel
The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity
Am J Physiol Endocrinol Metab, September 1, 2006; 291(3): E611 - E620.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
I. C. Okere, M. P. Chandler, T. A. McElfresh, J. H. Rennison, V. Sharov, H. N. Sabbah, K.-Y. Tserng, B. D. Hoit, P. Ernsberger, M. E. Young, et al.
Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin
Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H38 - H44.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. H. Kim, T. P. Stewart, W. Zhang, H. Y. Kim, P. M. Nishina, and J. K. Naggert
Type 2 diabetes mouse model TallyHo carries an obesity gene on chromosome 6 that exaggerates dietary obesity
Physiol Genomics, July 14, 2005; 22(2): 171 - 181.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
N. C. Jerez-Timaure, E. J. Eisen, and D. Pomp
Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2
Physiol Genomics, May 11, 2005; 21(3): 411 - 422.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. F. Deschepper, J. L. Olson, M. Otis, and N. Gallo-Payet
Characterization of blood pressure and morphological traits in cardiovascular-related organs in 13 different inbred mouse strains
J Appl Physiol, July 1, 2004; 97(1): 369 - 376.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
B. CANNON and J. NEDERGAARD
Brown Adipose Tissue: Function and Physiological Significance
Physiol Rev, January 1, 2004; 84(1): 277 - 359.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. E. Wortley, G.-Q. Chang, Z. Davydova, and S. F. Leibowitz
Peptides that Regulate Food Intake: Orexin gene expression is increased during states of hypertriglyceridemia
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1454 - R1465.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
B. K. Smith Richards, B. N. Belton, A. C. Poole, J. J. Mancuso, G. A. Churchill, R. Li, J. Volaufova, A. Zuberi, and B. York
QTL analysis of self-selected macronutrient diet intake: fat, carbohydrate, and total kilocalories
Physiol Genomics, December 3, 2002; 11(3): 205 - 217.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. W. Huggins, A. C. Boileau, and D. Y. Hui
Protection against diet-induced obesity and obesity- related insulin resistance in Group 1B PLA2-deficient mice
Am J Physiol Endocrinol Metab, November 1, 2002; 283(5): E994 - E1001.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
D. Chapelot and J. Louis-Sylvestre
Relevance of energy expenditure and energy intake to the etiology of obesity
Am. J. Clinical Nutrition, August 1, 2002; 76(2): 489 - 489.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. R. Jensen, E. C. Gayles, S. Ammon, R. Phillips, and R. H. Eckel
A self-correcting indirect calorimeter system for the measurement of energy balance in small animals
J Appl Physiol, March 1, 2001; 90(3): 912 - 918.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
L. Perusse and C. Bouchard
Gene-diet interactions in obesity
Am. J. Clinical Nutrition, November 1, 2000; 72 (5): 1285S - 1290S.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
D. B. West, F. Y. Blohm, A. A. Truett, and J. P. DeLany
Conjugated Linoleic Acid Persistently Increases Total Energy Expenditure in AKR/J Mice without Increasing Uncoupling Protein Gene Expression
J. Nutr., October 1, 2000; 130(10): 2471 - 2477.
[Abstract] [Full Text]

Home page
 J. Nutr.Home page
J. M. Lenhard, D. K. Croom, J. E. Weiel, A. Spaltenstein, D. J. Reynolds, and E. S. Furfine
Dietary Fat Alters HIV Protease Inhibitor-Induced Metabolic Changes in Mice
J. Nutr., September 1, 2000; 130(9): 2361 - 2366.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. Rippe, K. Berger, C. Boiers, D. Ricquier, and C. Erlanson-Albertsson
Effect of high-fat diet, surrounding temperature, and enterostatin on uncoupling protein gene expression
Am J Physiol Endocrinol Metab, August 1, 2000; 279(2): E293 - E300.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
K. Reue, P. Xu, X.-P. Wang, and B. G. Slavin
Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene
J. Lipid Res., July 1, 2000; 41(7): 1067 - 1076.
[Abstract] [Full Text]

Home page
 Physiol. GenomicsHome page
P. M. CORVA and J. F. MEDRANO
Diet effects on weight gain and body composition in high growth (hg/hg) mice
Physiol Genomics, June 29, 2000; 3(1): 17 - 23.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. K. Smith, P. K. Andrews, and D. B. West
Macronutrient diet selection in thirteen mouse strains
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2000; 278(4): R797 - R805.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
F. Du, D. A. Higginbotham, and B. D. White
Food Intake, Energy Balance and Serum Leptin Concentrations in Rats Fed Low-Protein Diets
J. Nutr., March 1, 2000; 130(3): 514 - 521.
[Abstract] [Full Text]

Home page
 HypertensionHome page
M. Barton, R. Carmona, H. Morawietz, L. V. d'Uscio, W. Goettsch, H. Hillen, C. C. Haudenschild, J. E. Krieger, K. Munter, T. Lattmann, et al.
Obesity Is Associated With Tissue-Specific Activation of Renal Angiotensin-Converting Enzyme In Vivo : Evidence for a Regulatory Role of Endothelin
Hypertension, January 1, 2000; 35(1): 329 - 336.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. Moitra, M. M. Mason, M. Olive, D. Krylov, O. Gavrilova, B. Marcus-Samuels, L. Feigenbaum, E. Lee, T. Aoyama, M. Eckhaus, et al.
Life without white fat: a transgenic mouse
Genes & Dev., October 15, 1998; 12(20): 3168 - 3181.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. Wang, J. T. Alexander, P. Zheng, H. J. Yu, J. Dourmashkin, and S. F. Leibowitz
Behavioral and endocrine traits of obesity-prone and obesity-resistant rats on macronutrient diets
Am J Physiol Endocrinol Metab, June 1, 1998; 274(6): E1057 - E1066.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. Rosenbaum, R. L. Leibel, and J. Hirsch
Obesity
N. Engl. J. Med., August 7, 1997; 337(6): 396 - 407.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. Gloaguen, P. Costa, A. Demartis, D. Lazzaro, A. Di Marco, R. Graziani, G. Paonessa, F. Chen, C. I. Rosenblum, L. H. T. Van der Ploeg, et al.
Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance
PNAS, June 10, 1997; 94(12): 6456 - 6461.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Liu, G.-Q. Chang, and S. F. Leibowitz
Diacylglycerol Kinase zeta in Hypothalamus Interacts with Long Form Leptin Receptor. RELATION TO DIETARY FAT AND BODY WEIGHT REGULATION
J. Biol. Chem., February 16, 2001; 276(8): 5900 - 5907.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Tartare-Deckert, C. Chavey, M.-N. Monthouel, N. Gautier, and E. Van Obberghen
The Matricellular Protein SPARC/Osteonectin as a Newly Identified Factor Up-regulated in Obesity
J. Biol. Chem., June 15, 2001; 276(25): 22231 - 22237.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. M. CHEVERUD, L. S. PLETSCHER, T. T. VAUGHN, and B. MARSHALL
Differential response to dietary fat in large (LG/J) and small (SM/J) inbred mouse strains
Physiol Genomics, July 15, 1999; 1(1): 33 - 39.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online