AJP - Regulatory, Integrative and Comparative Physiology, Vol 262, Issue 6 1064-R1069, Copyright © 1992 by American Physiological Society

ARTICLES

Central nervous system catecholamine content and norepinephrine release after AV3V ablation

J. W. Van Huysse and S. L. Bealer
Department of Physiology and Biophysics, University of Tennessee, Memphis 38163.

Electrolytic ablation of the periventricular tissue surrounding the anteroventral third cerebral ventricle (AV3V-X) results in immediate increases in norepinephrine release in the paraventricular hypothalamic nucleus/anterior hypothalamus (P/A) and in the dorsomedial medulla (DM) and depletion of norepinephrine and epinephrine throughout the brain. The present study determined whether catecholamine depletion and/or altered norepinephrine release persisted after recovery from the acute effects of AV3V-X. Fourteen to eighteen days after surgery, catecholamine concentrations throughout the brain and norepinephrine release in the P/A and DM during hemorrhage were measured in control-operated and AV3V-X rats. AV3V-X decreased epinephrine content only in the midbrain, increased norepinephrine only in the cortex, and produced no differences in central nervous system dopamine. Hemorrhage-induced norepinephrine release was significantly greater in the P/A of AV3V-X rats than in control animals, whereas norepinephrine release in the DM increased equally in both groups. Thus AV3V-X does not result in chronic global central nervous system catecholamine depletion and enhances norepinephrine release in the P/A during hemorrhage.

This article has been cited by other articles:

				S. L. Bealer and W. R. Crowley Noradrenergic control of central oxytocin release during lactation in rats Am J Physiol Endocrinol Metab, March 1, 1998; 274(3): E453 - E458. [Abstract] [Full Text] [PDF]

				K. Haugan, M. Shalmi, J. S. Petersen, N. Marcussen, J. Spannow, and S. Christensen Effects of Renal Papillary-Medullary Lesion on the Antihypertensive Effect of Furosemide and Development of Salt-Sensitive Hypertension in Dahl-S Rats J. Pharmacol. Exp. Ther., March 1, 1997; 280(3): 1415 - 1422. [Abstract] [Full Text]

				A. W. Cowley Jr, D. L. Mattson, S. Lu, and R. J. Roman The Renal Medulla and Hypertension Hypertension, April 1, 1995; 25(4): 663 - 673. [Abstract] [Full Text]