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Am J Physiol Regul Integr Comp Physiol 262: R1096-R1099, 1992;
0363-6119/92 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 262, Issue 6 1096-R1099, Copyright © 1992 by American Physiological Society

ARTICLES

Estradiol phase-shifts circannual rhythms of golden-mantled ground squirrels

T. M. Lee and I. Zucker
Department of Psychology, University of California, Berkeley 94720.

Ovariectomized golden-mantled ground squirrels (Spermophilus lateralis) were implanted with estradiol benzoate (EB)-filled or empty capsules. Body weight was monitored for at least 1 yr before, during, and after hormone treatment. EB treatment of 6-7 mo duration, restricted to the weight-gain phase, decelerated weight gain and delayed attainment of peak weight by 34 days; the period of the circannual rhythm, measured between successive trough weights, was 36 days longer in squirrels treated with estradiol than in untreated animals. EB treatment of 2- to 4-mo duration, restricted to the weight-loss phase, accelerated weight loss, advanced attainment of trough weights by 57 days, and decreased the period of the circannual rhythm by 66 days. Estradiol-induced phase delays and advances were preserved in the year after discontinuation of hormone treatment. These results favor the existence of circannual phase-response curves to hormones and provide a system for pharmacological manipulation of circannual rhythms.


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S. M. Hiebert, T. M. Lee, P. Licht, and I. Zucker
Estradiol phase shifts circannual body mass rhythms of male ground squirrels
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1998; 274(3): R754 - R759.
[Abstract] [Full Text] [PDF]


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