AJP - Regulatory, Integrative and Comparative Physiology, Vol 263, Issue 1 84-R88, Copyright © 1992 by American Physiological Society
Possible mediation by luminal somatostatin of bombesin-induced satiety in the cat
A. Bado, L. Moizo, J. P. Laigneau, M. Gauthier, M. Dubrasquet and M. J. Lewin
Institut National de la Sante et de la Recherche Medicale Unite 10, Hopital Bichat, Paris, France.
Intravenous bombesin produced a dose-related stimulation of luminal gastric
somatostatin output and a concomitant dose-dependent inhibition of food
intake in the gastric fistula cat. Maximal food intake inhibition was
observed at 1,280 pmol.kg-1.h-1 and corresponded to 65 +/- 7% (P less than
0.01). These effects of bombesin were dose dependently abolished by the
specific bombesin-receptor antagonist, [Leu13-psi(CH2NH)-Leu14]bombesin.
Furthermore, intragastric administration of somatostatin-14, at doses
corresponding to those found in the gastric lumen in response to
intravenously administered bombesin, significantly inhibited the first 30
min of food intake. This administration had however no effect on total
(daily) food intake. We therefore suggest that luminal gastric somatostatin
could at least account for bombesin-induced short-term satiety.
