AJP - Regulatory, Integrative and Comparative Physiology, Vol 263, Issue 4 954-R961, Copyright © 1992 by American Physiological Society
Indomethacin attenuates exercise-induced proteinuria in hypertensive miniature swine
K. P. O'Hagan, D. F. Hora Jr and E. J. Zambraski
Department of Biology, Rutgers University, New Brunswick, New Jersey 08903.
Exercise-induced proteinuria may be increased in hypertensives. The
mechanisms underlying the increased proteinuria are not known, and it has
not been determined whether animal models of hypertension exhibit a similar
response. We investigated whether indomethacin (Indo) altered
exercise-induced proteinuria in normal and hypertensive deoxycorticosterone
acetate (DOCA) Yucatan miniature swine (YMS). Five normal and four DOCA YMS
underwent 30 min of treadmill exercise at 80% of maximal heart rate.
Cumulative (exercise + recovery) albumin excretion in the DOCA YMS was
25-fold (P < 0.01) greater than observed in the normal YMS. Indo had no
effect on resting or exercise-induced proteinuria in the normal YMS.
However, Indo decreased the slightly elevated proteinuria at rest, and
normalized the exaggerated exercise-induced proteinuria in the DOCA YMS.
The antiproteinuric effect of Indo in the DOCA YMS was not associated with
altered exercise, recovery blood pressure, or glomerular filtration rate.
Thus hypertensive DOCA YMS exhibit an exaggerated exercise-induced
proteinuria. It is suggested that eicosanoids are involved in this abnormal
renal proteinuric response to exercise.
