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Am J Physiol Regul Integr Comp Physiol 263: R1049-R1056, 1992;
0363-6119/92 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 263, Issue 5 1049-R1056, Copyright © 1992 by American Physiological Society

ARTICLES

Cardiovascular responses to nasal water flow in rats are unaffected by chemoreceptor drive

P. F. McCulloch and N. H. West
Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.

Peripheral chemoreceptors generally play a limited role in the initial development of diving bradycardia in mammals. However, T.F. Huang and Y.I. Peng (Jpn. J. Physiol. 26: 395-401, 1976) reported that peripheral chemoreceptors are very important for manifestation of the diving response in conscious rats. The objectives of this study were to reinvestigate those findings and determine whether the cardiovascular responses to simulated diving in the rat were potentiated during preexisting hypoxia or hypercapnia. Responses to simulated diving were elicited by nasal water flow with concurrent apnea in paralyzed, artificially ventilated Sprague-Dawley rats anesthetized with Innovar. The experiments show that nasal stimulation in the rat results in rapid bradycardia and hypotension and that these responses are not due to laryngeal stimulation. The data also suggest that chemoreceptors do not play a role in the initiation of the responses to simulated diving in rats and that preexisting chemoreceptor drive does not alter the cardiovascular responses. Additionally, we found that concomitant expiratory apnea is necessary to sustain the profound initial cardiovascular changes induced by nasal water flow.


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G. P. Ollenberger and N. H. West
Contribution of hypercapnia and trigeminal stimulation to cerebrovascular dilation during simulated diving
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1998; 274(4): R921 - R930.
[Abstract] [Full Text] [PDF]


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