| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 263, Issue 5 1064-R1070, Copyright © 1992 by American Physiological Society
ARTICLES |
S. Lu, R. J. Roman, D. L. Mattson and A. W. Cowley Jr
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.
The role of renal papillary blood flow in regulation of fluid and electrolyte excretion was examined. The effects of an acute infusion of diltiazem (5 micrograms.kg-1 x min-1) into the renal medullary interstitium on papillary blood flow and sodium and water excretion were studied. Changes of renal blood flow were measured using an electromagnetic flow probe. Cortical and papillary blood flows were measured using laser-Doppler flowmetry. Renal and cortical blood flows were unchanged during medullary interstitial infusion of diltiazem, but papillary blood flow increased 26% (P < 0.05) and remained elevated for 1 h after diltiazem infusion was discontinued. Glomerular filtration rate (GFR) of the infused kidney increased by 21% from a control of 1.0 +/- 0.1 ml.min-1 x g-1 during infusion of diltiazem (P < 0.05), but it returned to control after diltiazem infusion was stopped. Urine flow and sodium excretion increased by 70% (P < 0.05), and fractional sodium excretion rose from 1.5 +/- 0.2 to 2.4 +/- 0.3% of the filtered load during the hour after diltiazem infusion. Renal blood flow, cortical and papillary blood flow, GFR, urine flow, and sodium excretion in the 0.9% sodium chloride vehicle-infused kidney were not significantly altered during the experiment. Intravenous infusion of the same dose of diltiazem (5 micrograms.kg-1 x min-1) increased GFR by 22%, but had no effect on urine flow and sodium excretion. These results indicate that renal medullary interstitial infusion of diltiazem selectively increased renal papillary blood flow, which was associated with an increase of sodium and water excretion.
This article has been cited by other articles:
|
|
 |
|
  D. Nakano, J. S. Pollock, and D. M. Pollock Renal medullary ETB receptors produce diuresis and natriuresis via NOS1 Am J Physiol Renal Physiol, May 1, 2008; 294(5): F1205 - F1211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. I. Boesen and D. M. Pollock Acute increases of renal medullary osmolality stimulate endothelin release from the kidney Am J Physiol Renal Physiol, January 1, 2007; 292(1): F185 - F191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kakoki, H.-S. Kim, W. J. Arendshorst, and D. L. Mattson L-Arginine uptake affects nitric oxide production and blood flow in the renal medulla Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1478 - R1485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Pallone, Z. Zhang, and K. Rhinehart Physiology of the renal medullary microcirculation Am J Physiol Renal Physiol, February 1, 2003; 284(2): F253 - F266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Tian, A. W. Gannon, R. A. Khalil, and R. D. Manning Jr. Mechanisms of salt-sensitive hypertension: role of renal medullary inducible nitric oxide synthase Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R372 - R379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mattson Importance of the renal medullary circulation in the control of sodium excretion and blood pressure Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R13 - R27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang, K. Rhinehart, and T. L. Pallone Membrane potential controls calcium entry into descending vasa recta pericytes Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R949 - R957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. W. Dukacz, M.-G. Feng, L.-F. Yang, R. M. K. W. Lee, and R. L. Kline Abnormal renal medullary response to angiotensin II in SHR is corrected by long-term enalapril treatment Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1076 - R1084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Correia, G. Bergstrom, A. J. Lawrence, and R. G. Evans Renal medullary interstitial infusion of norepinephrine in anesthetized rabbits: methodological considerations Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R112 - R122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-P. Zou, K. Nithipatikom, P.-L. Li, and A. W. Cowley Jr. Role of renal medullary adenosine in the control of blood flow and sodium excretion Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1999; 276(3): R790 - R798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Miyata, A. P. Zou, D. L. Mattson, and A. W. Cowley Jr. Renal medullary interstitial infusion of L-arginine prevents hypertension in Dahl salt-sensitive rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1667 - R1673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sadowski, L. Dobrowolski, and A. Walkowska Simultaneous recording of tissue ion content and blood flow in rat renal medulla: evidence on interdependence Am J Physiol Renal Physiol, October 1, 1997; 273(4): F658 - F662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Mattson and T. G. Bellehumeur Neural Nitric Oxide Synthase in the Renal Medulla and Blood Pressure Regulation Hypertension, August 1, 1996; 28(2): 297 - 303. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. B. Hansen, B. L. Jensen, D. Andreasen, and O. Skott Differential Expression of T- and L-Type Voltage-Dependent Calcium Channels in Renal Resistance Vessels Circ. Res., September 28, 2001; 89(7): 630 - 638. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
