AJP - Regu AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 264: R41-R50, 1993;
0363-6119/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vardhan, A.
Right arrow Articles by Sapru, H. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vardhan, A.
Right arrow Articles by Sapru, H. N.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 264, Issue 1 41-R50, Copyright © 1993 by American Physiological Society

ARTICLES

Excitatory amino acid receptors in commissural nucleus of the NTS mediate carotid chemoreceptor responses

A. Vardhan, A. Kachroo and H. N. Sapru
Section of Neurological Surgery, New Jersey Medical School, Newark 07103.

Stimulation of carotid body chemoreceptors by saline saturated with 100% CO2 elicited an increase in mean arterial pressure, respiratory rate, tidal volume, and minute ventilation (VE). Microinjections of L-glutamate into a midline area 0.5-0.75 mm caudal and 0.3-0.5 mm deep with respect to the calamus scriptorius increased VE. Histological examination showed that the site was located in the commissural nucleus of the nucleus tractus solitarii (NTS). The presence of excitatory amino acid receptors [N-methyl-D-aspartic acid (NMDA); kainate, quisqualate/alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) and trans 1-amino-cyclopentane-trans-1,3-dicarboxylic acid (ACPD)] in this area was demonstrated by microinjections of appropriate agonists. Simultaneous blockade of NMDA and non-NMDA receptors by combined injections of DL-2-aminophosphonoheptanoate (AP-7; 1 nmol) and 6,7-dinitro-quinoxaline-2,3-dione (DNQX; 1 nmol) abolished the responses to stimulation of carotid body on either side. Combined injections of AP-7 and DNQX did not produce a nonspecific depression of neurons because the responses to another agonist, carbachol, remained unaltered. Inhibition of the neurons in the aforementioned area with microinjections of muscimol (which hyperpolarizes neuronal cell bodies but not fibers of passage) also abolished the responses to subsequent carotid body stimulation on either side.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W.-Z. Wang, L. Gao, H.-J. Wang, I. H. Zucker, and W. Wang
Interaction between cardiac sympathetic afferent reflex and chemoreflex is mediated by the NTS AT1 receptors in heart failure
Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1216 - H1226.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. V. Gourine, N. Dale, A. Korsak, E. Llaudet, F. Tian, R. Huckstepp, and K. M. Spyer
Release of ATP and glutamate in the nucleus tractus solitarii mediate pulmonary stretch receptor (Breuer-Hering) reflex pathway
J. Physiol., August 15, 2008; 586(16): 3963 - 3978.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
S. R. Reeves and D. Gozal
Respiratory: Protein kinase C activity in the nucleus tractus solitarii is critically involved in the acute hypoxic ventilatory response, but is not required for intermittent hypoxia-induced phrenic long-term facilitation in adult rats
Exp Physiol, November 1, 2007; 92(6): 1057 - 1066.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. M. de Paula, G. Tolstykh, and S. Mifflin
Chronic intermittent hypoxia alters NMDA and AMPA-evoked currents in NTS neurons receiving carotid body chemoreceptor inputs
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2259 - R2265.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. J. Powers and C. E. Wood
Ketamine inhibits fetal ACTH responses to cerebral hypoperfusion
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1542 - R1549.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Chung, G. O. Ivy, and S. G. Reid
GABA-mediated neurotransmission in the nucleus of the solitary tract alters resting ventilation following exposure to chronic hypoxia in conscious rats
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1449 - R1456.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. G. Reid and F. L. Powell
Effects of chronic hypoxia on MK-801-induced changes in the acute hypoxic ventilatory response
J Appl Physiol, December 1, 2005; 99(6): 2108 - 2114.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. S. Moreira, M. A. Sato, A. C. T. Takakura, J. V. Menani, and E. Colombari
Role of pressor mechanisms from the NTS and CVLM in control of arterial pressure
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1416 - R1425.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. R. Reeves, E. S. Carter, S. Z. Guo, and D. Gozal
Calcium/calmodulin-dependent kinase II mediates critical components of the hypoxic ventilatory response within the nucleus of the solitary tract in adult rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R871 - R876.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. R. Reeves and D. Gozal
Platelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R369 - R374.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. A. Chianca Jr., L.-H. Lin, D. N. Dragon, and W. T. Talman
NMDA receptors in nucleus tractus solitarii are linked to soluble guanylate cyclase
Am J Physiol Heart Circ Physiol, April 1, 2004; 286(4): H1521 - H1527.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
W. T. Talman and D. N. Dragon
Transmission of Arterial Baroreflex Signals Depends on Neuronal Nitric Oxide Synthase
Hypertension, April 1, 2004; 43(4): 820 - 824.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. S. Orer, G. L. Gebber, S. W. Phillips, and S. M. Barman
Role of the medullary lateral tegmental field in reflex-mediated sympathoexcitation in cats
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2004; 286(3): R451 - R464.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. M. de Paula and B. H. Machado
Antagonism of adenosine A1 receptors in the NTS does not affect the chemoreflex in awake rats
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R2072 - R2078.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. F. Hayward
Evidence for alpha -2 adrenoreceptor modulation of arterial chemoreflexes in the caudal solitary nucleus of the rat
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1464 - R1473.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D.-P. Li, D. B. Averill, and H.-L. Pan
Differential roles for glutamate receptor subtypes within commissural NTS in cardiac-sympathetic reflex
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R935 - R943.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. A. Huey, M. J. Low, M. A. Kelly, R. Juarez, J. M. Szewczak, and F. L. Powell
Ventilatory responses to acute and chronic hypoxia in mice: effects of dopamine D2 receptors
J Appl Physiol, September 1, 2000; 89(3): 1142 - 1150.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. A. Sato, J. V. Menani, O. U. Lopes, and E. Colombari
Enhanced pressor response to carotid occlusion in commNTS-lesioned rats: possible efferent mechanisms
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2000; 278(5): R1258 - R1266.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. M. Whitney, P. J. Ohtake, N. Simakajornboon, Y.-D. Xue, and D. Gozal
AMPA glutamate receptors and respiratory control in the developing rat: anatomic and pharmacological aspects
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R520 - R528.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Gozal, G. A. Holt, G. R. Graff, and J. E. Torres
Platelet-activating factor modulates cardiorespiratory responses in the conscious rat
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1998; 275(2): R604 - R611.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. K. Coles, P. Ernsberger, and T. E. Dick
A role for NMDA receptors in posthypoxic frequency decline in the rat
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1998; 274(6): R1546 - R1555.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. J. Ohtake, J. E. Torres, Y. M. Gozal, G. R. Graff, and D. Gozal
NMDA receptors mediate peripheral chemoreceptor afferent input in the conscious rat
J Appl Physiol, March 1, 1998; 84(3): 853 - 861.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C.-S. Li and D. V. Smith
Glutamate Receptor Antagonists Block Gustatory Afferent Input to the Nucleus of the Solitary Tract
J Neurophysiol, March 1, 1997; 77(3): 1514 - 1525.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online