AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 264: R456-R459, 1993;
0363-6119/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Monda, M.
Right arrow Articles by Pittman, Q. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Monda, M.
Right arrow Articles by Pittman, Q. J.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 264, Issue 2 456-R459, Copyright © 1993 by American Physiological Society

ARTICLES

Cortical spreading depression blocks prostaglandin E1 and endotoxin fever in rats

M. Monda and Q. J. Pittman
Neuroscience Research Group, University of Calgary, Alberta, Canada.

We have tested the hypothesis that the cortex may play a role in the development of fever. Male Sprague-Dawley rats equipped with AM transmitters for telemetric measurement of body temperature were given intracerebroventricular prostaglandin E1 (PGE1), corticotropin-releasing hormone (CRH), or intravenous E. coli endotoxin. Application of cotton pellets soaked with 3.3 M KCl to the frontal cortex (to induce spreading depression) significantly reduced fevers to PGE1 and endotoxin when compared with fever magnitude with 0.9% NaCl application to the cortex. Neither CRH-induced hyperthermia nor normal body temperatures were altered by the spreading depression. Our results reveal a novel action of spreading depression on thermoregulatory function and indicate cortical involvement in the development of fever.


This article has been cited by other articles:


Home page
 Cereb CortexHome page
M. Monda, A. Viggiano, and V. De Luca
Functional Decortication Lowers Ventromedial Hypothalamic Activation Induced by Hippocampal Neostigmine Injection
Cereb Cortex, December 1, 2000; 10(12): 1242 - 1246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E.-L. M. Rollins and J. E. Fewell
Cerebral cortex does not modulate "regulated" decrease in core temperature during hypoxemia in rats
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1998; 274(4): R1158 - R1161.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online