AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 264: R733-R737, 1993;
0363-6119/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nilsson, G. E.
Right arrow Articles by Winberg, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nilsson, G. E.
Right arrow Articles by Winberg, S.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 264, Issue 4 733-R737, Copyright © 1993 by American Physiological Society

ARTICLES

Changes in the brain levels of GABA and related amino acids in anoxic shore crab (Carcinus maenas)

G. E. Nilsson and S. Winberg
Department of Zoophysiology, Uppsala University, Sweden.

The effects of anoxia on the brain concentrations of gamma-aminobutyric acid (GABA), glutamate, aspartate, glutamine, alanine, and taurine were measured in the shore crab (Carcinus maenas) and compared with data previously obtained from anoxia-tolerant vertebrates. C. maenas was found to survive 12 h in nitrogen-bubbled water. The changes found in brain amino acid levels were strikingly similar to those seen in anoxia-tolerant vertebrates. Thus, during anoxia, the brain of C. maenas displayed considerable increases in the concentrations of GABA (2.4-fold increase after 12 h) and alanine (8-fold increase after 12 h). By contrast, the brain levels of glutamate, aspartate, and glutamine fell significantly during anoxia, whereas the taurine level remained unchanged. Because GABA is a major inhibitory neurotransmitter in arthropods (as well as in most animal phyla), it is suggested that the increased level of GABA could promote the anoxic metabolic depression displayed by C. maenas and thus prolong anoxic survival. It is also possible that the decreases in glutamate and aspartate levels could play similar roles.


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
L. A. Sanni, C. Rae, A. Maitland, R. Stocker, and N. H. Hunt
Is Ischemia Involved in the Pathogenesis of Murine Cerebral Malaria?
Am. J. Pathol., September 1, 2001; 159(3): 1105 - 1112.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online