AJP - Regulatory, Integrative and Comparative Physiology, Vol 264, Issue 5 912-R916, Copyright © 1993 by American Physiological Society

ARTICLES

Abdominal vagotomy decreases the satiating potency of CCK-8 in sham and real feeding

K. Joyner, G. P. Smith and J. Gibbs
Department of Psychiatry, Cornell University Medical College, New York.

To compare the effect of total abdominal vagotomy on the satiating potency of cholecystokinin COOH-terminal octapeptide (CCK-8) in sham feeding and real feeding, we administered CCK-8 intraperitoneally (2, 4, and 8 micrograms/kg) 1 min before a sham feeding or real feeding intake test. CCK-8 was at least as potent for inhibiting intake during sham feeding as it was during real feeding. Total abdominal vagotomy decreased the satiating potency of all three doses of CCK-8 equally in both feeding conditions. These results are consistent with the proposal that abdominal vagal afferent fibers are as necessary for the mediation of the satiating effect of CCK-8 in sham feeding as they are in real feeding.

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