AJP - Regulatory, Integrative and Comparative Physiology, Vol 264, Issue 6 1119-R1124, Copyright © 1993 by American Physiological Society
Distribution and activity of dogfish NPY and peptide YY in the cardiovascular system of the common dogfish
C. Bjenning, N. Hazon, A. Balasubramaniam, S. Holmgren and J. M. Conlon
Gatty Marine Laboratory, St. Andrews, United Kingdom.
Neuropeptide Y is present in sympathetic nerves in the mammalian
cardiovascular system. This study has investigated the distribution of
neuropeptide Y in the cardiovascular and gastrointestinal systems and the
effect of dogfish neuropeptide Y and related peptides on cardiovascular
tissue of an elasmobranch fish, the common dogfish (Scyliorhinus canicula).
Neuropeptide Y-like immunoreactivity is present in varicose nerve fibers
innervating dogfish gut and cardiovascular tissue and in endocrine cells of
the dogfish spiral intestine. Dogfish neuropeptide Y, dogfish peptide YY,
and porcine neuropeptide Y contract the dogfish afferent branchial artery
in a concentration-dependent manner. The effect is not inhibited by the
presence of tetrodotoxin or by removal of the endothelium. The mammalian Y1
receptor selective agonist [Leu31Pro34]NPY but not the mammalian Y2
receptor selective agonist neuropeptide Y-(13-36) peptide has
vasoconstrictor properties in this system, suggesting that the receptor
mediating the vasoconstriction resembles the mammalian Y1 receptor more
than the Y2 receptor.
