AJP - Regulatory, Integrative and Comparative Physiology, Vol 264, Issue 6 1214-R1218, Copyright © 1993 by American Physiological Society
Estrogens and antiestrogens: actions and interactions with fluphenazine on food intake and body weight in rats
J. M. Gray, S. Schrock and M. Bishop
Department of Psychology, Vassar College, Poughkeepsie, New York 12601.
Treatment of ovariectomized rats for 3 days with 2 micrograms estradiol
benzoate (E2B), 6 micrograms ethinyl estradiol, or 1-2 mg of either of the
antiestrogens nafoxidine or tamoxifen led to similar decreases in food
intake, body weight gain, adipose tissue lipoprotein lipase activity, and
hepatic fatty acid synthetase activity, despite their different effects on
uterine growth and induction of progestin receptors in pituitary and
adipose tissue. Longer-term (2 wk) treatment with tamoxifen resulted in
similar transient changes in food intake and body weight gain, as did
treatment with E2B. Daily administration of 50 micrograms fluphenazine
(FLU) led to significant decreases in body weight, although there was no
change in food intake. Concurrent administration of FLU with either E2B or
tamoxifen led to additive effects on body weight and food intake change.
None of the treatments had any effect on in vitro binding of [3H]tamoxifen
to antiestrogen binding sites in pooled hypothalamic-preoptic area samples.
