AJP - Regu Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 265: R1-R6, 1993;
0363-6119/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kaufman, L. N.
Right arrow Articles by Gilardy, A. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaufman, L. N.
Right arrow Articles by Gilardy, A. K.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 265, Issue 1 1-R6, Copyright © 1993 by American Physiological Society

ARTICLES

Adrenal medulla as a mediator of diet-induced hypertension

L. N. Kaufman, H. Y. Li, M. M. Peterson and A. K. Gilardy
Department of Physiology, Michigan State University, East Lansing 48824.

Male Sprague-Dawley rats fed either a high-fat or glucose-enriched diet for 10 wk developed higher blood pressure (BP) and higher urinary catecholamine excretion than rats fed a control diet. After 10 wk of diet treatment, systolic BP was 164 +/- 3, 156 +/- 2, and 145 +/- 4 mmHg in rats fed the high-fat, glucose, and control diets, respectively (P < 0.02 vs. control). During weeks 7-9 of diet treatment, excretion of epinephrine and norepinephrine was increased in hypertensive rats (those fed the high-fat or glucose diet) when compared with rats fed the control diet (P < 0.001). The purpose of this study was to determine whether the hypertensive response to nutrients could be prevented by prior surgical removal of the adrenal medulla. Adrenal demedullation nearly abolished epinephrine excretion, attenuated norepinephrine excretion, and completely blocked the hypertensive response to dietary fat and glucose. These findings suggest that adrenal medullary catecholamines play a role in the hypertensive response to nutrients.


This article has been cited by other articles:


Home page
 FASEB J.Home page
Z. Michailidou, R. N. Carter, E. Marshall, H. G. Sutherland, D. G. Brownstein, E. Owen, K. Cockett, V. Kelly, L. Ramage, E. A. S. Al-Dujaili, et al.
Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet
FASEB J, November 1, 2008; 22(11): 3896 - 3907.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
I. Matsumoto, A. Niijima, Y. Oomura, K. Sasaki, K. Tsuchiya, and T. Aikawa
Acidic fibroblast growth factor activates adrenomedullary secretion and sympathetic outflow in rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R1003 - R1012.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Bao, N. Metreveli, R. Li, A. Taylor, and E. C. Fletcher
Blood pressure response to chronic episodic hypoxia: role of the sympathetic nervous system
J Appl Physiol, July 1, 1997; 83(1): 95 - 101.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online