| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 265, Issue 1 235-R239, Copyright © 1993 by American Physiological Society
ARTICLES |
K. A. Fraser and J. S. Davison
Department of Medical Physiology, University of Calgary, Alberta, Canada.
Sprague-Dawley rats injected with a "physiological" dose of cholecystokinin octapeptide (CCK-8; 6 micrograms/kg ip) expressed c-fos immunoreactivity in the nucleus of the tractus solitarius (NTS) and the area postrema (AP) of the brain stem. Injection of the CCK-A antagonist L-364,718 30 min before CCK-8 injection eliminated c-fos expression in these regions. These findings support the hypothesis that CCK-8 induced c-fos expression is mediated by CCK-A receptors. We then tested whether a meal (Isocal) could activate c-fos, and, if so, whether this response could be eliminated by L-364,718. Ingestion of Isocal induced c-fos immunoreactivity in the NTS and AP. Meal-induced c-fos expression was not blocked by the CCK-A antagonist L-364,718. These findings demonstrate for the first time that a purely physiological nonnoxious stimulus, a meal, induces c-fos in the rat brain stem and indicate that feeding induces c-fos expression by a pathway that is largely, if not entirely, independent of CCK release.
This article has been cited by other articles:
|
|
 |
|
  K. L. Whited, D. Thao, K. C. K. Lloyd, A. S. Kopin, and H. E. Raybould Targeted disruption of the murine CCK1 receptor gene reduces intestinal lipid-induced feedback inhibition of gastric function Am J Physiol Gastrointest Liver Physiol, July 1, 2006; 291(1): G156 - G162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. H. E. M. van de Wall, P. Duffy, and R. C. Ritter CCK enhances response to gastric distension by acting on capsaicin-insensitive vagal afferents Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R695 - R703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Angeles-Castellanos, J. Mendoza, M. Diaz-Munoz, and C. Escobar Food entrainment modifies the c-Fos expression pattern in brain stem nuclei of rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R678 - R684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tatewaki, M. Harris, K. Uemura, T. Ueno, E. Hoshino, A. Shiotani, T. N. Pappas, and T. Takahashi Dual effects of acupuncture on gastric motility in conscious rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2003; 285(4): R862 - R872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. K. Lloyd, J. Wang, and T. E. Solomon Acid inhibition by intestinal nutrients mediated by CCK-A receptors but not plasma CCK Am J Physiol Gastrointest Liver Physiol, October 1, 2001; 281(4): G924 - G930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Eckel and N. Geary Estradiol treatment increases feeding-induced c-Fos expression in the brains of ovariectomized rats Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R738 - R746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Glatzle, M. E. Kreis, K. Kawano, H. E. Raybould, and T. T. Zittel Postprandial neuronal activation in the nucleus of the solitary tract is partly mediated by CCK-A receptors Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R222 - R229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Emond, G. J. Schwartz, and T. H. Moran Meal-related stimuli differentially induce c-Fos activation in the nucleus of the solitary tract Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1315 - R1321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, S. Cardin, V. Martinez, Y. Tache, and K. C. K. Lloyd Duodenal loading with glucose induces Fos expression in rat brain: selective blockade by devazepide Am J Physiol Regulatory Integrative Comp Physiol, September 1, 1999; 277(3): R667 - R674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Horn, A. Addis, and M. I. Friedman Neural substrate for an integrated metabolic control of feeding behavior Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1999; 276(1): R113 - R119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rinaman, E. A. Baker, G. E. Hoffman, E. M. Stricker, and J. G. Verbalis Medullary c-Fos activation in rats after ingestion of a satiating meal Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1998; 275(1): R262 - R268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Hansen, L. Kapas, J. Fang, and J. M. Krueger Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy in rats Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1998; 274(1): R168 - R174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Monnikes, G. Lauer, C. Bauer, J. Tebbe, T. T. Zittel, and R. Arnold Pathways of Fos expression in locus ceruleus, dorsal vagal complex, and PVN in response to intestinal lipid Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1997; 273(6): R2059 - R2071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Pomonis, A. S. Levine, and C. J. Billington Interaction of the Hypothalamic Paraventricular Nucleus and Central Nucleus of the Amygdala in Naloxone Blockade of Neuropeptide Y-Induced Feeding Revealed by c-fos Expression J. Neurosci., July 1, 1997; 17(13): 5175 - 5182. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
