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Am J Physiol Regul Integr Comp Physiol 265: R609-R614, 1993;
0363-6119/93 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 265, Issue 3 609-R614, Copyright © 1993 by American Physiological Society

ARTICLES

Gastric vagus mediates immobilization-induced hypocalcemia in rats

J. Ma, S. Aou, H. Matsui and T. Hori
Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

The involvement of the parasympathetic nervous system in the etiology of stress-induced hypocalcemia was investigated in the rat. Atropine methyl bromide (0.1 and 0.6 mg/kg ip) given 20 min before immobilization (IMB) was observed to suppress the induction of hypocalcemia in a dose-dependent manner. A vagotomy of the bilateral cervical trunks also abolished the IMB-induced hypocalcemia. A vagotomy on either the thyroid/parathyroid branches or the celiac branches had no effect on the IMB-induced hypocalcemia, but a vagotomy on the gastric branches completely abolished it. Pretreatment with either secretin (2 and 6 micrograms/kg ip), an inhibitor of gastrin release, or cimetidine (5 and 10 mg/kg ip), a histamine H2-receptor antagonist, diminished the IMB-induced hypocalcemia. The concentration of serum gastrin increased significantly during IMB. It is thus concluded that the decreased levels of plasma calcium caused by IMB are due to the activation of the vagus innervating the stomach. Gastrin and histamine are also involved as a consequence of the activation of the vagus.


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K. Shiramine, S. Aou, and T. Hori
Lateral hypothalamic injection of GABAA antagonist induces gastric vagus-mediated hypocalcemia in the rat
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1997; 273(4): R1492 - R1500.
[Abstract] [Full Text] [PDF]


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