| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 265, Issue 4 726-R732, Copyright © 1993 by American Physiological Society
ARTICLES |
R. K. Dubey, H. Y. Zhang, S. R. Reddy, M. A. Boegehold and T. A. Kotchen
Department of Medicine, School of Medicine, West Virginia University, Morgantown 26506.
Hypertension is frequently associated with insulin resistance. We evaluated the effects of pioglitazone, an agent that increases insulin sensitivity, on the development of hypertension in the Dahl salt-sensitive (Dahl-S) rat and in the one-kidney, one-clip Sprague-Dawley rat. We also evaluated the effects of pioglitazone on growth of cultured preglomerular renal arteriolar smooth muscle cells. In Dahl-S rats fed a 3% NaCl diet, tail systolic blood pressures and direct arterial pressures were lower (P < 0.05) in pioglitazone-treated (20 mg/kg daily by gavage for 3 wk) than in control rats (n = 10 rats/group). In one-kidney, one-clip Sprague-Dawley rats, systolic blood pressures were also lower in pioglitazone-treated animals (P < 0.0001). In vitro, proliferation of arteriolar smooth muscle cells was stimulated (P < 0.01) by insulin, epidermal growth factor (EGF), and fetal calf serum (FCS); pioglitazone (5 microM) reversibly inhibited (P < 0.01) insulin-, EGF-, and FCS-induced proliferation. Pioglitazone (0.01-100 microM) also inhibited insulin- (1 mU/ml), EGF- (100 ng/ml), and 5% FCS-induced [3H]thymidine incorporation in a concentration-dependent manner (P < 0.01). Thus pioglitazone attenuated the development of hypertension in the Dahl-S rat and the one-kidney, one-clip rat. The ability of pioglitazone to inhibit growth of vascular smooth muscle may contribute to its hypotensive effect.
This article has been cited by other articles:
|
|
 |
|
  L. M. Bivol, M. Hultstrom, O. A. Gudbrandsen, R. K. Berge, and B. M. Iversen Tetradecylthioacetic acid downregulates cyclooxygenase 2 in the renal cortex of two-kidney, one-clip hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1866 - R1873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Bivol, R. K. Berge, and B. M. Iversen Differential effect of tetradecythioacetic acid on the renin-angiotensin system and blood pressure in SHR and 2-kidney, 1-clip hypertension Am J Physiol Renal Physiol, September 1, 2007; 293(3): F839 - F845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Crossno Jr., C. V. Garat, J. E. B. Reusch, K. G. Morris, E. C. Dempsey, I. F. McMurtry, K. R. Stenmark, and D. J. Klemm Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling Am J Physiol Lung Cell Mol Physiol, April 1, 2007; 292(4): L885 - L897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. K. Rehan, Y. Wang, S. Sugano, J. Santos, S. Patel, R. Sakurai, L. W. Boros, W.-P. Lee, and J. S. Torday In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L323 - L333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yamamoto, R. Ohki, R. T. Lee, U. Ikeda, and K. Shimada Peroxisome Proliferator-Activated Receptor {gamma} Activators Inhibit Cardiac Hypertrophy in Cardiac Myocytes Circulation, October 2, 2001; 104(14): 1670 - 1675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Aizawa, J.-i. Kawabe, N. Hasebe, N. Takehara, and K. Kikuchi Pioglitazone Enhances Cytokine-Induced Apoptosis in Vascular Smooth Muscle Cells and Reduces Intimal Hyperplasia Circulation, July 24, 2001; 104(4): 455 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Hsueh, S. Jackson, and R. E. Law Control of Vascular Cell Proliferation and Migration by PPAR-{gamma}: A new approach to the macrovascular complications of diabetes Diabetes Care, February 1, 2001; 24(2): 392 - 397. [Abstract] [Full Text]
|
|
|
|
|
|
K. Takeda, T. Ichiki, T. Tokunou, Y. Funakoshi, N. Iino, K. Hirano, H. Kanaide, and A. Takeshita Peroxisome Proliferator-Activated Receptor {gamma} Activators Downregulate Angiotensin II Type 1 Receptor in Vascular Smooth Muscle Cells Circulation, October 10, 2000; 102(15): 1834 - 1839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. H. Sung, J. L. Izzo Jr, P. Dandona, and M. F. Wilson Vasodilatory Effects of Troglitazone Improve Blood Pressure at Rest and During Mental Stress in Type 2 Diabetes Mellitus Hypertension, July 1, 1999; 34(1): 83 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hattori, S. Hattori, and K. Kasai Troglitazone Upregulates Nitric Oxide Synthesis in Vascular Smooth Muscle Cells Hypertension, April 1, 1999; 33(4): 943 - 948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Moore, M. A. Maher, W. J. Banz, and M. B. Zemel Chromium Picolinate Modulates Rat Vascular Smooth Muscle Cell Intracellular Calcium Metabolism J. Nutr., February 1, 1998; 128(2): 180 - 184. [Abstract] [Full Text]
|
|
|
|
|
|
T. A. Kotchen Attenuation of Hypertension by Insulin-Sensitizing Agents Hypertension, August 1, 1996; 28(2): 219 - 223. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
