AJP - Regu Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


Am J Physiol Regul Integr Comp Physiol 265: R786-R791, 1993;
0363-6119/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Inoue, S.
Right arrow Articles by Murase, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Inoue, S.
Right arrow Articles by Murase, T.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 265, Issue 4 786-R791, Copyright © 1993 by American Physiological Society


ARTICLES

Determinants of fasting hypertriglyceridemia in ventromedial hypothalamic obesity in rats

S. Inoue, S. Satoh, K. Tanaka, Y. Takamura and T. Murase
Third Department of Internal Medicine, Yokohama City University, Japan.

The present study investigated the mechanism of fasting hypertriglyceridemia in ventromedial hypothalamic (VMH) obesity by measurement of post-heparin plasma lipoprotein lipase (LPL) activity, triglyceride secretion rate (TGSR), and plasma insulin. One week after VMH lesions, when the lesioned rats were gaining weight rapidly (the dynamic phase), they showed normal plasma triglyceride levels with increased plasma LPL activity and TGSR. There was a positive correlation between hyperinsulinemia and elevated plasma LPL activity or TGSR in VMH-lesioned rats, while no correlation was observed in control rats. Ten weeks after VMH lesions, when the rats had become obese and reached a steady-state weight gain (the static phase), they showed hypertriglyceridemia with increased plasma LPL activity and TGSR. There was, again, a positive correlation between hyperinsulinemia and elevated plasma LPL activity or TGSR in VMH-lesioned rats. These results suggest a possible mechanism of fasting hypertriglyceridemia in these rats; in the dynamic phase adipose tissue adequately takes up circulating triglyceride because the tissue has sufficient take-up capacity and hence hypertriglyceridemia does not develop. In the static phase the tissue cannot adequately take up circulating triglyceride because of a limitation of its capacity, resulting in hypertriglycemia despite enhanced triglyceride secretion and increased LPL activity in both phases.


This article has been cited by other articles:


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
T. Hirano, T. Takahashi, S. Saito, H. Tajima, T. Ebara, and M. Adachi
Apoprotein C-III deficiency markedly stimulates triglyceride secretion in vivo: comparison with apoprotein E
Am J Physiol Endocrinol Metab, October 1, 2001; 281(4): E665 - E669.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
A. Suga, T. Hirano, H. Kageyama, T. Osaka, Y. Namba, M. Tsuji, M. Miura, M. Adachi, and S. Inoue
Effects of fructose and glucose on plasma leptin, insulin, and insulin resistance in lean and VMH-lesioned obese rats
Am J Physiol Endocrinol Metab, April 1, 2000; 278(4): E677 - E683.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
A. Suga, T. Hirano, S. Inoue, M. Tsuji, T. Osaka, Y. Namba, M. Miura, and M. Adachi
Plasma leptin levels and triglyceride secretion rates in VMH-lesioned obese rats: a role of adiposity
Am J Physiol Endocrinol Metab, April 1, 1999; 276(4): E650 - E657.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
M. Shimada, S. Ishibashi, T. Gotoda, M. Kawamura, K. Yamamoto, T. Inaba, K. Harada, J. Ohsuga, S. Perrey, Y. Yazaki, et al.
Overexpression of Human Lipoprotein Lipase Protects Diabetic Transgenic Mice From Diabetic Hypertriglyceridemia and Hypercholesterolemia
Arterioscler Thromb Vasc Biol, October 1, 1995; 15(10): 1688 - 1694.
[Abstract] [Full Text]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online