AJP - Regu AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 265: R826-R833, 1993;
0363-6119/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thornton, S. N.
Right arrow Articles by Nicolaidis, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thornton, S. N.
Right arrow Articles by Nicolaidis, S.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 265, Issue 4 826-R833, Copyright © 1993 by American Physiological Society

ARTICLES

Blood pressure effects of iontophoretically applied bioactive hormones in the anterior forebrain of the rat

S. N. Thornton and S. Nicolaidis
Centre National de la Recherche Scientifique, Unite de Recherche Associee 637, Laboratoire de Neurobiologie des Regulations, College de France, Paris.

In the course of electrophysiological investigations using iontophoresis, we observed that in specific regions of the forebrain even these minute applications of peptide and steroid hormones can influence systemic blood pressure. In urethan-anesthetized male Wistar rats, with a catheter in the femoral artery, iontophoretic application of the peptide hormones angiotensin II (ANG II), vasopressin (AVP), and atrial natriuretic peptide (ANP) and the steroid hormone aldosterone (ALDO) was effective at locations in the midline septum, the triangularis nucleus of the septum, and the subfornical organ (SFO). Increases in blood pressure (of up to 15 mmHg) were observed after ANG II and AVP, decreases after ALDO, and either an increase or a decrease, depending on the location, after ANP. There was no clear evidence of an antagonistic effect of ANP on ANG II-induced neuronal or blood pressure responses. In addition to demonstrating the potency of these hormones even when they are restricted to tiny volumes of tissue, the present results demonstrate that the medial ventral region of the anterior forebrain may be included in the same baroreceptive circuit as the SFO (and organ vasculosum of the lamina terminalis) and hence be involved in the regulation of blood volume and perhaps in the sensing of and corrective responses to extracellular thirst.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
J. ANTUNES-RODRIGUES, M. DE CASTRO, L. L. K. ELIAS, M. M. VALENCA, and S. M. McCANN
Neuroendocrine Control of Body Fluid Metabolism
Physiol Rev, January 1, 2004; 84(1): 169 - 208.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. T. FITZSIMONS
Angiotensin, Thirst, and Sodium Appetite
Physiol Rev, July 1, 1998; 78(3): 583 - 686.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. Anthes, H. A. Schmid, M. Hashimoto, T. Riediger, and E. Simon
Heterogeneous actions of vasopressin on ANG II-sensitive neurons in the subfornical organ of rats
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1997; 273(6): R2105 - R2111.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online