AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 265: R1253-R1261, 1993;
0363-6119/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Basile, D. P.
Right arrow Articles by Holzwarth, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Basile, D. P.
Right arrow Articles by Holzwarth, M. A.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 265, Issue 6 1253-R1261, Copyright © 1993 by American Physiological Society

ARTICLES

Basic fibroblast growth factor may mediate proliferation in the compensatory adrenal growth response

D. P. Basile and M. A. Holzwarth
Department of Physiology and Biophysics, University of Illinois, Urbana 61801.

We have investigated the role of basic fibroblast growth factor (bFGF) in the neurally mediated compensatory adrenal growth response. Unilateral adrenalectomy resulted in a 13, 6, and 22% increase in adrenal weight, protein, and DNA content, respectively, and 33-40% increases in the rate of cell proliferation measured by [3H]thymidine incorporation in vitro. Three forms of bFGF, approximately 18.6, 21, and 22.5 kDa, were identified in rat adrenals by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot. bFGF was localized immunocytochemically in cells of the glomerulosa and the medulla. bFGF stimulated a 68-80% increase in the rate of DNA synthesis in adrenal capsule-glomerulosa preparations in vitro. Suramin (0.1 mM), a growth factor antagonist, blocked bFGF receptor interaction in vitro and, at 200 mg/kg given 5-7 days before adrenal surgery, blocked compensatory growth. Conversely, at 2.0 mg/kg, suramin significantly enhanced the compensatory growth response, perhaps caused by suramin-induced bFGF receptor upregulation, since suramin pretreatment also enhanced DNA synthesis in response to exogenous bFGF in vitro. These results suggest that bFGF may mediate proliferation in the compensatory adrenal growth response.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. C. Engeland, W. B. Ennen, A. Elayaperumal, D. A. Durand, and B. K. Levay-Young
Zone-specific cell proliferation during compensatory adrenal growth in rats
Am J Physiol Endocrinol Metab, February 1, 2005; 288(2): E298 - E306.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y. M. Ulrich-Lai, D. J. Marek, and W. C. Engeland
Capsaicin-sensitive adrenal sensory fibers participate in compensatory adrenal growth in rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R877 - R884.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. P. Shepherd and M. A. Holzwarth
Chromaffin-adrenocortical cell interactions: effects of chromaffin cell activation in adrenal cell cocultures
Am J Physiol Cell Physiol, January 1, 2001; 280(1): C61 - C71.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
H. H. Boersma, J. W. Wensing, T. L. Kho, L. M. de Brauw, I. H. Liem, and M. J.P.G. van Kroonenburgh
Transient Enhanced Uptake of 123I-Metaiodobenzylguanidine in the Contralateral Adrenal Region after Resection of an Adrenal Pheochromocytoma
N. Engl. J. Med., May 11, 2000; 342(19): 1450 - 1450.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online