AJP - Regulatory, Integrative and Comparative Physiology, Vol 265, Issue 6 1399-R1403, Copyright © 1993 by American Physiological Society

ARTICLES

ICI 182,780 antagonizes the effects of estradiol on estrous behavior and energy balance in Syrian hamsters

G. N. Wade, J. B. Powers, J. D. Blaustein and D. E. Green
Department of Psychology, University of Massachusetts, Amherst 01003.

Three experiments examined the effects of ICI 182,780, a steroidal "pure" antiestrogen that is thought to be active peripherally but not in the brain when given systemically, on energy balance, estrous behavior, and in vivo cell nuclear binding of [3H]estradiol in Syrian hamsters. Pretreatment with ICI 182,780 reduced in vivo uptake of [3H]estradiol in uterus but not in pooled hypothalamus-preoptic area. Ovariectomized Syrian hamsters were treated with estradiol benzoate (EB, 5 micrograms/day), ICI 182,780 (250 micrograms/day), or both EB and ICI 182,780 for 4 wk. Estradiol treatment caused significant decreases in food intake, body weight and fat content, and linear growth. Given alone, ICI 182,780 had no effect on these measures. When they were given concurrently, ICI 182,780 attenuated the effects of estradiol on body weight, growth, and fat content but not on food intake. Treatment with ICI 182,780 significantly diminished estrous behavior induced with either EB plus progesterone or with EB alone. These findings support the hypothesis that, in addition to its actions in the brain, estradiol acts peripherally to modulate estrous behavior and energy balance.

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