AJP - Regulatory, Integrative and Comparative Physiology, Vol 266, Issue 2 381-R386, Copyright © 1994 by American Physiological Society
Metabolic influences on satiety in rats receiving parenteral nutrition
J. L. Beverly, M. M. Meguid, Z. J. Yang, M. X. Yue and B. L. Fetterman
Department of Surgery, State University of New York Health Science Center, University Hospital, Syracuse 13210.
Food intake is reduced during parenteral nutrition (PN) proportionally to
the amount of calories or composition of the solution infused. The relative
importance of infused glucose and lipid, 50 and 30% of PN kilocalories,
respectively, in reducing food intake during PN was examined. Glycolysis,
fatty acid oxidation, or both were acutely disrupted with 2-deoxy-D-glucose
(2-DG) and mercaptoacetate (MA). Rats receiving intravenous infusions of
saline or a PN solution providing 100% of total daily calories (PN-100)
received a single intraperitoneal injection of saline, 2-DG, and/or MA
during the early light phase. 2-DG (1.4 or 2.2 mmol/kg) did not initiate
feeding in PN-100 rats, although hyperglycemia was evident in all rats 1 h
after 2-DG. Food intake of PN-100 rats after MA (0.4 mmol/kg) was
approximately 50% that of control rats. When 2-DG (1.4 mmol/kg) and MA (0.4
mmol/kg) were administered concomitantly, PN-100 and control rats consumed
the same amount of food. During PN-100, rats appeared to be more sensitive
to losing metabolic energy derived from lipid than from glucose.
